Immune Checkpoint Inhibition (Tremelimumab and/or MEDI4736) in Combination With Radiation Therapy in Patients With Unresectable Pancreatic Cancer

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

65

Participants

Timeline

Start Date

March 25, 2015

Primary Completion Date

October 23, 2019

Study Completion Date

December 31, 2020

Conditions
Pancreatic NeoplasmsPancreatic CancerCancer of PancreasCancer of the PancreasPancreas Cancer
Interventions
BIOLOGICAL

Durvalumab

10 mg/kg, mg intravenous (IV), every two weeks, or 1500 mg, IV, every four weeks.

BIOLOGICAL

Tremelimumab

75 mg IV, every 4 weeks for 16 weeks

RADIATION

Sterostatic body radiation therapy (SBRT)

8 Gray (Gy) x 1; 5Gy x 5

Trial Locations (1)

20892

National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH

NCT02311361 - Immune Checkpoint Inhibition (Tremelimumab and/or MEDI4736) in Combination With Radiation Therapy in Patients With Unresectable Pancreatic Cancer | Biotech Hunter | Biotech Hunter