22
Participants
Start Date
May 31, 2014
Primary Completion Date
June 30, 2014
Study Completion Date
June 30, 2014
Dofetilide
"* 8 am: Placebo~* 12 pm (noon): 250 µg~* 5:30 pm: 250 µg"
Mexiletine
"* 8 am: weight x 4 mg/kg~* 12 pm (noon): Same as at 8 am~* 5:30 pm: Same as at 8 am"
Lidocaine
"* 9 am : 30 µg/min per kg (loading) for 60 minutes and 10 µg/min per kg (maintenance) for 30 minutes~* 2 pm: 55 µg/min per kg (loading) for 60 minutes and 20 µg/min per kg (maintenance) for 30 minutes~* 7:30 pm: 52 µg/min per kg (loading) for 60 minutes and 20 µg/min per kg (maintenance) for 30 minutes"
Moxifloxacin
"* 9 am: 5.63 mg/h per kg (loading) for 1 hour and 0.26 mg/h per kg (maintenance for 30 minutes)~* 2 pm: 6.14 mg/h per kg (loading) for 1 hour and 0.49 mg/h per kg (maintenance for 30 minutes)~* 7:30 pm: 2.23 mg/h per kg (loading) for 1 hour and 0.49 mg/h per kg (maintenance for 30 minutes)"
Diltiazem
• 7:30 pm: 330 µg/h per kg (loading) for 60 minutes and 61 µg/h per kg (maintenance) for 30 minutes
Placebo
Placebo (#2 Gelcap or IV saline)
Spaulding Clinical Research LLC
OTHER
Food and Drug Administration (FDA)
FED