225
Participants
Start Date
July 31, 2013
Primary Completion Date
August 1, 2021
Study Completion Date
February 28, 2026
Bevacizumab
10mg/kg IV (in the vein) on Days 1 and 15 of a 4 week cycle, for 6 cycles or until progression
Temozolomide
200mg/m2/d PO (capsule taken orally) on Days 1 to 5 of a 4 week cycle, for 6 cycles or until progression
Temozolomide
100mg/m2/d PO (capsule taken orally) on Days 1 to 5 of a 3 week cycle, for 6 cycles or until progression
Irinotecan
50mg/m2/d IV (in the vein) on Days 1 to 5 of a 3 week cycle, for 6 cycles or until progression
Bevacizumab
15mg/kg IV (in the vein) on Day 1 of a 3 week cycle, for 6 cycles or until progression
Topotecan
0.75mg/m2/d IV (in the vein) on Days 1-5 of a 4 week cycle, for 6 cycles or until progression
Temozolomide
150mg/m2/d PO (capsule taken orally) on Days 1 to 5 of a 4 week cycle, for 6 cycles or until progression
Dinutuximab Beta
10mg/m2/d IV (in the vein) on Days 1 to 7 of a 4 week cycle, for 6 cycles or until progression
Cyclophosphamide
250mg/m2/d IV (in the vein) on Days 1 to 5 of a 4 week cycle, for 6 cycles or until progression
Swiss Paediatric Oncology Group, Bern
Hopital des Enfants, Toulouse
Instituto de Investigacion Sanitaria, Valencia
St Anna Children's Hospital and CCRI/Studies and Statistics, Vienna
University Hospital, Ghent
Natasha van Eijkelenburg, Utrecht
University Hospital Rigshospitalet, Copenhagen
Our Ladys Children's Hospital Dublin, Dublin
Ospedale Pediatrico Bambino Gseu, Rome
The Royal Marsden NHS Foundation Trust and Institute of Cancer Research, Sutton
Collaborators (2)
Cancer Research UK
OTHER
Roche Pharma AG
INDUSTRY
Imagine for Margo
UNKNOWN
EUSA Pharma, Inc.
INDUSTRY
University of Birmingham
OTHER