76
Participants
Start Date
March 31, 2015
Primary Completion Date
November 30, 2017
Study Completion Date
November 30, 2017
Exenatide
The starting dose of exenatide is 5 ug bid, subcutaneously, for 4 weeks, followed by 10 ug bid, subcutaneously, for 20 weeks. If hypoglycaemia (blood glucose\<2.9 mmol/l or \< 3.9 mmol/l at least 2 times) or serious intolerance occurs, the dose will be adjusted to 5 ug bid, subcutaneously.
insulin glargine
"The starting dose of insulin glargine will depend upon the HbA1c level at screening(HbA1c \<8% use 0.1 -0.2 U/kg per day;HbA1c \>8% use 0.2 -0.3 U/kg per day).~Dose adjustment protocol for insulin glargine (at least 3 determinations of fasting blood glucose per week):~fasting blood glucose(FBG) \> 180 mg/dL(10 mmol/l): add 4 U; FBG 140-180 mg/dL(7.8-10 mmol/l): add 2 U; FBG 126-139 mg/dL(7.0-7.8 mmol/l): add 1 U.~If hypoglycemia, reduce insulin glargine by:~blood glucose \<70mg/dl（3.9mmol/l）: 10%-20%; blood glucose \<40mg/dl（2.2mmol/l）: 20%-40%."
Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai
Department of Endocrinology and Metabolism, Shanghai Minhang Central Hospital, Shanghai
Department of Endocrinology and Metabolism,Huadong Hospital, Shanghai
Department of Endocrinology and Metabolism,Shanghai 6th People's Hospital, Shanghai
Department of Endocrinology and Metabolism,Shanghai Changzheng Hospital, Shanghai
Huadong Hospital
OTHER
Shanghai Minhang Central Hospital
OTHER
Shanghai 6th People's Hospital
OTHER
Shanghai Changzheng Hospital
OTHER
Fudan University
OTHER