A Study of Atezolizumab Compared With Chemotherapy in Participants With Locally Advanced or Metastatic Urothelial Bladder Cancer [IMvigor211]

PHASE3CompletedINTERVENTIONAL
Enrollment

931

Participants

Timeline

Start Date

January 13, 2015

Primary Completion Date

March 13, 2017

Study Completion Date

November 8, 2018

Conditions
Bladder Cancer
Interventions
DRUG

Atezolizumab (MPDL3280A) [TECENTRIQ], an engineered anti-PDL1 antibody

Atezolizumab will be administered intravenously at a fixed dose of 1200 mg on Day 1 of each 21-day cycle.

DRUG

Docetaxel

Docetaxel 75 mg/m\^2 will be administered intravenously on Day 1 of each 21-day cycle.

DRUG

Paclitaxel

Paclitaxel 175 mg/m\^2 will be administered intravenously on Day 1 of each 21-day cycle.

DRUG

Vinflunine

Vinflunine 320 mg/m\^2 will be administered intravenously on Day 1 of each 21-day cycle.

Trial Locations (217)

100

National Taiwan Uni Hospital; Dept of Oncology, Taipei

407

Taichung Veterans General Hospital; Division of Urology, Taichung

1000

Institut Jules Bordet, Brussels

Institute of Oncology Ljubljana, Ljubljana

1082

Semmelwies University of Medicine; Urology Dept., Budapest

1090

Medizinische Universität Wien; Univ.Klinik für Innere Medizin I - Abt. für Onkologie, Vienna

1100

Kaiser-Franz-Josef-Spital; Zent.Onkologie und Hamatologie, Vienna

1122

"Orszagos Onkologiai Intezet; C Belgyógyászati-Onkológiai és Klinikai Farmakológiai Osztály", Budapest

1145

Uzsoki Utcai Korhaz, Budapest

1211

HUG; Oncologie, Geneva

2020

ZNA Middelheim, Antwerp

2100

Rigshospitalet; Onkologisk Klinik, København Ø

2730

Herlev Hospital; Onkologisk afdeling, Herlev

3000

UZ Leuven Gasthuisberg, Leuven

3010

Inselspital Bern; Universitätsklinik für medizinische Onkologie, Bern

3084

Austin and Repatriation Medical Centre; Cancer Services, Melbourne

3168

Monash Medical Centre; Oncology, Clayton

4029

Royal Brisbane and Women's Hospital; Medical Oncology, Herston

4604

Sørlandet Sykehus Kristiansand, Kristiansand

5000

Royal Adelaide Hospital; Oncology, Adelaide

5004

Hetenyi Geza County Hospital; Onkologiai Kozpont, Szolnok

6000

Kecskemeti Onkoradilogai Centrum, Kecskemét

6351

Samsung Medical Center, Seoul

7000

St. Olavs Hospital; Kreftavdelingen, Trondheim

Kantonsspital Graubünden;Onkologie und Hämatologie, Chur

8091

UniversitätsSpital Zürich; Zentrum für Hämatologie und Onkologie, Klinik für Onkologie, Zurich

9000

UZ Gent, Ghent

9007

Kantonsspital St. Gallen; Onkologie/Hämatologie, Sankt Gallen

9019

Uni Hospital of Tromso; Dept. of Oncology, Tromsø

10003

Hospital San Pedro De Alcantara; Servicio de Oncologia, Cáceres

10060

Fondazione Del Piemonte Per L'oncologia Ircc Di Candiolo; Dipartimento Oncologico, Candiolo

11000

Clinical Center of Serbia; Clinic of Urology, Belgrade

Institute for Oncology and Radiology of Serbia; Medical Oncology, Belgrade

11217

TAIPEI VETERANS GENERAL HOSPITAL, Urology, Taipei

12200

Charité - Universitätsmedizin Berlin; CC 8: Chirurgische Medizin; Klinik für Urologie, Berlin

13009

Institut J Paolii Calmettes, Marseille

14004

Hospital Universitario Reina Sofia; Servicio de Oncologia, Córdoba

14076

Centre Francois Baclesse; Recherche Clinique, Caen

15706

Complejo Hospitalario Universitario de Santiago (CHUS) ; Servicio de Oncologia, Santiago de Compostela

16059

Uludag Uni Hospital; Oncology, Bursa

20007

Georgetown University Medical Center Lombardi Cancer Center, Washington D.C.

20133

Irccs Istituto Nazionale Dei Tumori (Int);S.C. Medicina Oncologica 2, Milan

20246

Universitätsklinikum Hamburg-Eppendorf Onkologisches Zentrum Medizinische Klinik II, Hamburg

20520

Turku University Central Hospital; Urology clinic, Turku

21204

Oncology Institute of Vojvodina, Kamenitz

22770

Trakya University Medical Faculty Research And Practice Hospital Medical Oncology Department, Edirne

24127

Asst Papa Giovanni XXIII; Oncologia Medica, Bergamo

25030

Chr De Besancon - Hopital Jean Minjoz, Besançon

26100

ASST DI CREMONA; Dip. Medicina - S.C. Oncologia, Cremona

27710

Duke Cancer Center, Durham

28007

Hospital General Universitario Gregorio Marañon; Servicio de Oncologia, Madrid

28034

Hospital Ramon y Cajal; Servicio de Oncologia, Madrid

28040

Hospital Universitario Clínico San Carlos; Servicio de Oncologia, Madrid

28041

Hospital Universitario 12 de Octubre; Servicio de Oncologia, Madrid

29010

Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia, Málaga

29607

Bon Secours - St. Francis Hospital, Greenville

30029

CHU De Nimes, Hopital Caremeau; Service De Neurologie Du Prof. Pierre Labauge, Nîmes

30308

Emory University; Winship Cancer Institute, Atlanta

31008

Hospital de Navarra; Servicio de Oncologia, Navarra

Clinica Universitaria de Navarra; Servicio de Oncologia, Pamplona

31059

Institut Claudius Regaud; Departement Oncologie Medicale, Toulouse

33075

Hopital Saint Andre, Bordeaux

33076

Institut Bergonie; Oncologie, Bordeaux

33100

A.O. Universitaria S. Maria Della Misericordia Di Udine; Oncologia, Udine

34286

Bezmialem Vakif Univ Medical, Istanbul

34298

Institut régional du Cancer Montpellier, Montpellier

34300

Istanbul Uni Cerrahpasa Medical Faculty Hospital; Medical Oncology, Istanbul

34365

Istanbul VKV American Hospital; Medical Oncology, Istanbul

35100

Ege Uni Medical Faculty Hospital; Oncology Dept, Izmir

37075

Universitätsmedizin Göttingen Georg-August-Universität; Klinik für Urologie, Göttingen

37232

Vanderbilt-Ingram Cancer Ctr, Nashville

39120

Universitätsklinikum Magdeburg A.ö.R., Klinik f. Urologie u. Kinderurologie, Magdeburg

40225

Universitätsklinikum Düsseldorf; Urologische Klinik, Düsseldorf

40447

China Medical University Hospital; Urology, Taichung

41013

Hospital Universitario Virgen del Rocio; Servicio de Oncologia, Seville

41014

Hospital General Universitario de Valencia; Servicio de oncologia, Valencia

41100

A.O. Universitaria Policlinico Di Modena; Oncologia, Modena

44280

Inonu University Medical Faculty Turgut Ozal Medical Center Medical Oncology Department, Malatya

44805

ICO - Site René Gauducheau, Saint-Herblain

46010

Hospital Clínico Universitario de Valencia; Servicio de Oncología, Valencia

47014

IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica, Meldola

49000

Ico - Paul Papin, Angers

50139

Azienda Ospedaliero-Universitaria Careggi;S.C. Oncologia Medica 1, Florence

52074

Uniklinik RWTH Aachen; Klinik für Urologie, Aachen

52100

Azienda USL8 Arezzo-Presidio Ospedaliero 1 San Donato;U.O.C. Oncologia, Arezzo

54100

Centre D'Oncologie de Gentilly; Oncology, Nancy

66424

Universitätsklinikum des Saarlandes; Klinik für Urologie und Kinderurologie, Homburg/Saar

67098

Hopital Hautepierre; Hematologie Oncologie, Strasbourg

68167

Medizinische Fakultät Mannheim, Universitätsklinikum Mannheim, Klinik für Urologie, Mannheim

69120

Nationales Centrum für Tumorerkrankungen Heidelberg (NCT); Thoraxklinik Heidelberg, Heidelberg

69373

Centre Leon Berard; Departement Oncologie Medicale, Lyon

69495

Centre Hospitalier Lyon Sud, Pierre-Bénite

71013

IRCCS Ospedale Casa Sollievo Della Sofferenza; Oncologia, San Giovanni Rotondo

72076

Universitätsklinikum Tübingen; Klinik für Urologie, Tübingen

75014

Hopital Cochin; Unite Fonctionnelle D Oncologie, Paris

75231

Institut Curie; Recherche Clinique, Paris

75475

Hopital Saint Louis; Oncologie Medicale, Paris

75908

Hopital Europeen Georges Pompidou; Service D'Oncologie Medicale, Paris

76031

CHU de Rouen - Hôpital Charles Nicolle, Rouen

79106

Universitätsklinikum Freiburg; Chirurgische Klinik; Abteilung Urologie, Freiburg im Breisgau

80131

Azienda Ospedaliera A. Cardarelli; Dip. Oncopneumoematologico, Napoli

81675

Klinikum rechts der Isar der TU München; Urologische Klinik und Poliklinik, München

84918

Institut Sainte Catherine;Recherche Clinique, Avignon

87039

Clinique Chenieux; Oncology, Limoges

89081

Universitätsklinikum Ulm; Klinik für Urologie, Ulm

89128

Comprehensive Cancer Centers of Nevada, Las Vegas

90146

Casa Di Cura Di Alta Specialita La Maddalena; Dept. Oncologico Di Iii Livello, Palermo

91054

Friedrich-Alexander-Universität Erlangen-Nürnberg; Medizinische Klinik V, Erlangen

92151

Hopital Foch; Oncologie, Suresnes

94010

CHU Henri Mondor; Service d'Oncologie Medicale, Créteil

94805

Institut Gustave Roussy; Departement Oncologie Medicale, Villejuif

125284

Federal State Institution, Moscow Research Oncology Institute n.a. P.A. Hertzen; Oncourology, Moscow

198255

St. Petersburg Oncology Hospital, Saint Petersburg

200347

Oncology Center Sf. Nectarie, Craiova

300239

ONCOMED - Medical Centre, Timișoara

355045

SBI of Healthcare of Stavropol region Stavropol Regional Clinical Oncology Dispensary, Stavropol

400015

Institut Oncologic Ion Chiricuta; Departament Radioterapie, Cluj-Napoca

430031

Spitalul Judetean de Urgenta Dr Constantin Opris, Baia Mare

540142

Spital Clinic Judetean Mures; Oncologie, Târgu Mureş

603001

GBUZ Nizhegorodskay Region: Clinical Diagnostic Center, Nizhny Novgorod

656049

Altai Regional Oncological Center, Barnaul

700106

Euroclinic Center of Oncology SRL, Iași

T2N 4N2

Tom Baker Cancer Centre-Calgary, Calgary

V1Y 5L3

Bcca - Cancer Center Southern Interior, Kelowna

V5Z 4E6

BCCA-Vancouver Cancer Centre, Vancouver

V8R 6V5

Bcca - Vancouver Island Cancer Centre; Oncology, Victoria

L4M 6M2

Royal Victoria Hospital, Barrie

N6A 4L6

London Regional Cancer Centre, London

L1G 2B9

Lakeridge Health Oshawa; Oncology, Oshawa

K1H 8L6

The Ottawa Hospital Cancer Centre; Oncology, Ottawa

P6A 2C4

Sault Area Hospitals, Sault Ste. Marie

M4N 3M5

Sunnybrook Odette Cancer Centre, Toronto

H3T 1E2

McGill University; Sir Mortimer B Davis Jewish General Hospital; Oncology, Montreal

656 53

Masarykuv onkologicky ustav, Brno

775 20

Fakultni nemocnice Olomouc, Olomouc

532 03

MULTISCAN, s.r.o., Radiologicke centrum Pardubice, Pardubice

100 34

Fakultni nemocnice Kralovske Vinohrady, Prague

128 08

Vseobecna fakultni nemocnice v Praze, Prague

00180

Docrates Cance Center, Helsinki

06189

Centre Antoine Lacassagne, Nice

01307

"Universitätsklinikum Carl Gustav Carus; Klinik und Poliklinik für Urologie", Dresden

115 28

Alexandras General Hospital of Athens; Oncology Department, Athens

711 10

Univ General Hosp Heraklion; Medical Oncology, Heraklion

265 04

University Hospital of Patras Medical Oncology, Pátrai

546 45

Euromedical General Clinic of Thessaloniki; Oncology Department, Thessaloniki

00152

Azienda Ospedaliera San Camillo Forlanini; Oncologia Medica, Rome

466-8560

Nagoya University Hospital; Urology, Aichi

036-8563

Hirosaki University School of Medicine & Hospital; Urology, Aomori

260-8717

Chiba Cancer Center; Urology, Chiba

277-8577

National Cancer Center Hospital East; Breast and Medical Oncology, Chiba

791-0280

National Hospital Organization Shikoku Cancer Center; Urology, Ehime

812-0033

Harasanshin Hospital; Urology, Fukuoka

812-8582

Kyushu University Hospital; Urology, Fukuoka

371-8511

Gunma University Hospital; Urology, Gunma

730-8518

Hiroshima City Hiroshima Citizens Hospital; Urology, Hiroshima

060-8543

Sapporo Medical University Hospital; Urology, Hokkaido

060-8648

Hokkaido University Hospital; Urology, Hokkaido

305-8576

University of Tsukuba Hospital; Urology, Ibaraki

236-0004

Yokohama City University Hospital; Urology, Kanagawa

860-8556

Kumamoto University Hospital; Urology, Kumamoto

951-8566

Niigata Cancer Center Hospital;Urology, Niigata

020-8505

Iwate Medical University Hospital; Urology, Numakunai

541-8567

Osaka International Cancer Institute; Urology, Osaka

565-0871

Osaka University Hospital; Urology, Osaka

589-8511

Kindai University Hospital; Urology, Osaka

411-8777

Shizuoka Cancer Center; Urology, Shizuoka

770-8503

Tokushima University Hospital; Urology, Tokushima

104-0045

National Cancer Center Hospital; Urology, Tokyo

105-8470

Toranomon Hospital; Medical Oncology, Tokyo

113-8603

Nippon Medical School Hospital; Urology, Tokyo

135-8550

The Cancer Institute Hospital, JFCR; Urology, Tokyo

1066 CX

The Netherlands Cancer Institute - Antoni Van Leeuwenhoekziekenhuis, Amsterdam

2134 TM

Spaarne Ziekenhuis; Inwendige Geneeskunde, Hoofddorp

6229 HX

Maastricht University Medical Centre; Medical Oncology, Maastricht

3430 EM

St. Antonius Ziekenhuis Nieuwegein, Nieuwegein

8011 JW

Isala Klinieken, Zwolle

15-027

Medical University of Bialystok; Oncology clinic, Bialystok

80-214

Uniwersyteckie Centrum Kliniczne, Klinika Onkologii i Radioterapii, Gdansk

20-090

COZL Oddzial Onkologii Klinicznej z pododdzialem Chemioterapii Dziennej, Lublin

60-569

Oddzial Chemioterapii Szpitala Klinicznego Nr 1 w Poznaniu, Poznan

02-781

Centrum onkologii Instytutu im. Marii Sklodowskiej-Curie; Klinika Nowotworow Ukladu Moczowego, Warsaw

50-556

Uniwersytecki Szpital Kliniczny im. Jana Miklulicza-Radeckiego we Wrocławiu; Departament Of Urology, Wroclaw

1649-035

Hospital de Santa Maria; Servico de Oncologia Medica, Lisbon

2674-514

Hospital Beatriz Angelo; Departamento de Oncologia, Loures

4200-072

IPO do Porto; Servico de Oncologia Medica, Porto

022338

Institute Of Oncology Bucharest; Medical Oncology, Bucharest

03080

Seoul National University Hospital, Seoul

05505

Asan Medical Center - Oncology, Seoul

07014

Hospital Universitario Son Espases; Servicio de Oncologia, Palma de Mallorca

08208

Corporacio Sanitaria Parc Tauli; Servicio de Oncologia, Sabadell

08035

Hospital Univ Vall d'Hebron; Servicio de Oncologia, Barcelona

08036

Hospital Clinic i Provincial; Servicio de Farmacia, Barcelona

08041

Hospital de la Santa Creu i Sant Pau; Servicio de Oncologia, Barcelona

08908

Institut Catala d Oncologia Hospital Duran i Reynals, Barcelona

413 45

Sahlgrenska Universitetssjukhuset; Jubileumskliniken, Gothenburg

171 76

Karolinska Hospital; Oncology - Radiumhemmet, Stockholm

090185

Norrlands Uni Hospital; Onkologi Avd., Umeå

06100

Hacettepe Uni Medical Faculty Hospital; Oncology Dept, Sıhhiye, Ankara

B15 2TH

University Hospital Birmingham The Cancer Centre, Queen Elizabeth Hospital, Birmingham

BS2 8ED

Bristol Haematology and Oncology Centre, Bristol

CB2 0QQ

Addenbrooke's Hospital, Cambridge

GL53 7AN

Cheltenham General Hospital, Cheltenham

CV2 2DX

University Hospital coventry; Oncology Department, Coventry

EX2 5DW

Royal Devon & Exeter Hospital; Oncology Centre, Exeter

LA1 4RP

Royal Lancaster Infirmary, Morecambe Bay Hospitals Nhs Trust, Lancaster

LS9 7TF

St James Institute of Oncology, Leeds

LE1 5WW

Leicester Royal Infirmary; Dept. of Medical Oncology, Leicester

EC1M 6BQ

Barts and The London, London

NW3 2QG

Royal Free Hospital; Dept of Oncology, London

CH63 4JY

The Clatterbridge Cancer Centre NHS Foundation Trust, Metropolitan Borough of Wirral

NE7 7DN

Northern Centre for Cancer Care; Northern Centre for Cancer Care, Newcastle upon Tyne

NG5 1PB

Nottingham City Hospital, Nottingham

OX3 7LJ

Churchill Hospital, Oxford

DN16 7BH

Scunthorpe General Hospital; Dept of Oncology, Scunthorpe

SO16 6YD

Southampton General Hospital; Medical Oncology, Southampton

SM2 5PT

Royal Marsden Hospital; Dept of Medical Oncology, Sutton

TR1 3LQ

Royal Cornwall Hospital, Truro

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT02302807 - A Study of Atezolizumab Compared With Chemotherapy in Participants With Locally Advanced or Metastatic Urothelial Bladder Cancer [IMvigor211] | Biotech Hunter | Biotech Hunter