SAFIR02_Breast - Efficacy of Genome Analysis as a Therapeutic Decision Tool for Patients With Metastatic Breast Cancer

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

1,460

Participants

Timeline

Start Date

April 7, 2014

Primary Completion Date

December 31, 2022

Study Completion Date

December 31, 2025

Conditions
Metastatic Breast Cancer
Interventions
DRUG

AZD2014

Target: m-TOR

DRUG

AZD4547

Target: EGFR

DRUG

AZD5363

Target: AKT

DRUG

AZD8931

Target: HER2, EGFR

DRUG

Selumetinib

Target: MEK

DRUG

Vandetanib

Target: VEGF, EGFR

DRUG

Bicalutamide

target: Androgen receptor

DRUG

Olaparib

Target: PARP

DRUG

Anthracyclines

DNA intercalation

DRUG

Taxanes

Target: mitotic tubulin and microtubules

DRUG

cyclophosphamide

Alkylating agents

DRUG

DNA intercalators

DNA intercalators

DRUG

Methotrexate

DNA intercalators

DRUG

vinca alkaloids

Target: mitotic tubulin and microtubules

DRUG

Platinum based chemotherapies

Platinum based chemotherapies

DRUG

Bevacizumab

Target: VEGF

DRUG

Mitomycin C

Alkylating agents

DRUG

Eribulin

Microtubule modulator

DRUG

MEDI4736

Target: PD-L1

Trial Locations (25)

21079

Centre Georges François Leclerc, Dijon

33077

Polyclinique Bordeaux Nord Aquitaine, Bordeaux

74200

Hopitaux Du Leman, Thonon-les-Bains

85925

Chd Vendee, La Roche-sur-Yon

87000

Chu Dupuytren, Limoges

Unknown

Institut de Cancérologie de l'Ouest/Paul Papin, Angers

Institut Sainte-Catherine, Avignon

Institut Bergonié, Bordeaux

Centre François Baclesse, Caen

Centre Jean Perrin, Clermont-Ferrand

Centre Oscar Lambret, Lille

Centre Hospitalier Lyon Sud, Lyon

Centre Léon Bérard, Lyon

Institut Paoli Calmettes, Marseille

Institut Régional du Cancer Montpellier Val d'Aurelle, Montpellier

Centre Alexis Vautrin, Nancy

Institut de Cancérologie de l'Ouest/ René Gauducheau, Nantes

Centre Antoine Lacassagne, Nice

Institut Curie, Paris

Centre Eugène Marquis, Rennes

Centre Henri Becquerel, Rouen

Institut Curie, Saint-Cloud

Hopitaux Universitaire de Strasbourg - Hopital Civil, Strasbourg

Institut Claudius Regaud, Toulouse

Gustave Roussy, Villejuif

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Fondation ARC

OTHER

collaborator

AstraZeneca

INDUSTRY

lead

UNICANCER

OTHER