105
Participants
Start Date
December 31, 2014
Primary Completion Date
November 30, 2016
Study Completion Date
July 6, 2020
DNA Nat-B env
4 mg to be administered as 1 mL intramuscularly (IM) by Biojector 2000® or with a needle and syringe in the deltoid muscle of the non-dominant arm (unless medically contraindicated)
DNA CON-S env
4 mg to be administered as 1 mL IM by Biojector 2000® or with a needle and syringe in the deltoid muscle of the non-dominant arm (unless medically contraindicated)
DNA Mosaic env
4 mg to be administered as 1 mL IM by Biojector 2000® or with a needle and syringe in the deltoid muscle of the non-dominant arm (unless medically contraindicated)
MVA-CMDR
1×10\^8 plaque forming units (pfu) to be administered as 1 mL IM in the deltoid muscle of the non-dominant arm (unless medically contraindicated)
Placebo for DNA Nat-B env
Sodium Chloride for Injection, 0.9% to be administered as 1 mL IM by Biojector 2000® or with a needle and syringe in the deltoid muscle of the non-dominant arm (unless medically contraindicated)
Placebo for DNA CON-S env
Sodium Chloride for Injection, 0.9% to be administered as 1 mL IM by Biojector 2000® or with a needle and syringe in the deltoid muscle of the non-dominant arm (unless medically contraindicated)
Placebo for DNA Mosaic env
Sodium Chloride for Injection, 0.9% to be administered as 1 mL IM by Biojector 2000® or with a needle and syringe in the deltoid muscle of the non-dominant arm (unless medically contraindicated)
Placebo for MVA-CMDR
Sodium Chloride for Injection, 0.9% to be administered as 1 mL IM in the deltoid muscle of the non-dominant arm (unless medically contraindicated)
Lausanne Vaccine and Immunotherapy Center CRS, Lausanne
The Hope Clinic of the Emory Vaccine Center CRS, Decatur
Alabama CRS, Birmingham
Bridge HIV CRS, San Francisco
Brigham and Women's Hospital Vaccine CRS (BWH VCRS), Boston
Fenway Health (FH) CRS, Boston
Seattle Vaccine and Prevention CRS, Seattle
CHAVI
UNKNOWN
IPPOX Foundation
OTHER
MHRP
UNKNOWN
HIV Vaccine Trials Network
NETWORK
National Institute of Allergy and Infectious Diseases (NIAID)
NIH