Evaluating the Safety and Immune Response to Three Different DNA HIV Vaccines Administered With a MVA-CMDR Boost Vaccine in Healthy, HIV-Uninfected Adults

PHASE1CompletedINTERVENTIONAL
Enrollment

105

Participants

Timeline

Start Date

December 31, 2014

Primary Completion Date

November 30, 2016

Study Completion Date

July 6, 2020

Conditions
HIV Infections
Interventions
BIOLOGICAL

DNA Nat-B env

4 mg to be administered as 1 mL intramuscularly (IM) by Biojector 2000® or with a needle and syringe in the deltoid muscle of the non-dominant arm (unless medically contraindicated)

BIOLOGICAL

DNA CON-S env

4 mg to be administered as 1 mL IM by Biojector 2000® or with a needle and syringe in the deltoid muscle of the non-dominant arm (unless medically contraindicated)

BIOLOGICAL

DNA Mosaic env

4 mg to be administered as 1 mL IM by Biojector 2000® or with a needle and syringe in the deltoid muscle of the non-dominant arm (unless medically contraindicated)

BIOLOGICAL

MVA-CMDR

1×10\^8 plaque forming units (pfu) to be administered as 1 mL IM in the deltoid muscle of the non-dominant arm (unless medically contraindicated)

BIOLOGICAL

Placebo for DNA Nat-B env

Sodium Chloride for Injection, 0.9% to be administered as 1 mL IM by Biojector 2000® or with a needle and syringe in the deltoid muscle of the non-dominant arm (unless medically contraindicated)

BIOLOGICAL

Placebo for DNA CON-S env

Sodium Chloride for Injection, 0.9% to be administered as 1 mL IM by Biojector 2000® or with a needle and syringe in the deltoid muscle of the non-dominant arm (unless medically contraindicated)

BIOLOGICAL

Placebo for DNA Mosaic env

Sodium Chloride for Injection, 0.9% to be administered as 1 mL IM by Biojector 2000® or with a needle and syringe in the deltoid muscle of the non-dominant arm (unless medically contraindicated)

BIOLOGICAL

Placebo for MVA-CMDR

Sodium Chloride for Injection, 0.9% to be administered as 1 mL IM in the deltoid muscle of the non-dominant arm (unless medically contraindicated)

Trial Locations (7)

1011

Lausanne Vaccine and Immunotherapy Center CRS, Lausanne

30030

The Hope Clinic of the Emory Vaccine Center CRS, Decatur

35294

Alabama CRS, Birmingham

94143

Bridge HIV CRS, San Francisco

02115-6110

Brigham and Women's Hospital Vaccine CRS (BWH VCRS), Boston

02215-4302

Fenway Health (FH) CRS, Boston

98109-1024

Seattle Vaccine and Prevention CRS, Seattle

All Listed Sponsors
collaborator

CHAVI

UNKNOWN

collaborator

IPPOX Foundation

OTHER

collaborator

MHRP

UNKNOWN

collaborator

HIV Vaccine Trials Network

NETWORK

lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

NCT02296541 - Evaluating the Safety and Immune Response to Three Different DNA HIV Vaccines Administered With a MVA-CMDR Boost Vaccine in Healthy, HIV-Uninfected Adults | Biotech Hunter | Biotech Hunter