Comparison of SAR342434 to Humalog as the Rapid Acting Insulin in Adult Patients With Type 2 Diabetes Mellitus Also Using Insulin Glargine

PHASE3CompletedINTERVENTIONAL
Enrollment

505

Participants

Timeline

Start Date

January 31, 2015

Primary Completion Date

February 29, 2016

Study Completion Date

February 29, 2016

Conditions
Type 2 Diabetes Mellitus
Interventions
DRUG

SAR342434

SAR342434 100 U/mL (dose range of 1 Unit to 80 Units) self-administered by subcutaneous (SC) injection, immediately (within 5 -10 minutes) before meals intake. Dose adjusted to achieve 2 hour post prandial glucose (PPG) in range of 6.7 to 8.9 mmol/L (120 to 160 mg/dL) while avoiding hypoglycemia.

DRUG

Humalog

Humalog 100 U/ml (dose range of 1 unit to 60 units) self-administered by SC injection, immediately (within 5-10 minutes) before meals intake. Dose adjusted to achieve a 2 hour PPG in range of 6.7 to 8.9 mmol/L (120 to 160 mg/dL) while avoiding hypoglycemia.

DRUG

insulin glargine HOE901

Insulin glargine 100 U/mL injected QD subcutaneously consistent with the local label. Doses adjusted to achieve glycemic target for fasting, preprandial plasma glucose (SMPG) between 4.4 to 7.2 mmol/L (80 to 130 mg/dL) without hypoglycemia.

Trial Locations (103)

1036

Investigational Site Number 348205, Budapest

1135

Investigational Site Number 348202, Budapest

2900

Investigational Site Number 348208, Komárom

3980

Investigational Site Number 348209, Sátoraljaújhely

4032

Investigational Site Number 348204, Debrecen

4400

Investigational Site Number 032203, Salta

5004

Investigational Site Number 348203, Szolnok

8800

Investigational Site Number 348210, Nagykanizsa

10115

Investigational Site Number 276201, Berlin

14469

Investigational Site Number 276206, Potsdam

15401

Investigational Site Number 840243, Uniontown

16684

Investigational Site Number 840250, Tipton

20099

Investigational Site Number 380202, Sesto San Giovanni

20132

Investigational Site Number 380201, Milan

20852

Investigational Site Number 840239, Rockville

24534

Investigational Site Number 276202, Neumünster

27408

Investigational Site Number 840232, Greensboro

28557

Investigational Site Number 840211, Morehead City

28655

Investigational Site Number 840228, Morganton

29010

Investigational Site Number 724203, Málaga

30046

Investigational Site Number 840253, Lawrenceville

30281

Investigational Site Number 840207, Stockbridge

33176

Investigational Site Number 840246, Miami

33472

Investigational Site Number 840214, Boynton Beach

33952

Investigational Site Number 840242, Port Charlotte

34303

Investigational Site Number 792201, Istanbul

34652

Investigational Site Number 840226, New Port Richey

34684

Investigational Site Number 840206, Palm Harbor

34761

Investigational Site Number 840205, Ocoee

34890

Investigational Site Number 792202, Istanbul

35100

Investigational Site Number 792204, Izmir

35340

Investigational Site Number 792203, Izmir

35661

Investigational Site Number 840237, Muscle Shoals

36535

Investigational Site Number 840217, Foley

37404

Investigational Site Number 840208, Chattanooga

38305

Investigational Site Number 840215, Jackson

40138

Investigational Site Number 380203, Bologna

43201

Investigational Site Number 840221, Columbus

45439

Investigational Site Number 840255, Dayton

46123

Investigational Site Number 840204, Avon

47714

Investigational Site Number 840257, Evansville

48085

Investigational Site Number 840236, Troy

50314

Investigational Site Number 840230, Des Moines

58103

Investigational Site Number 840225, Fargo

60005

Investigational Site Number 840248, Arlington Heights

68521

Investigational Site Number 840216, Lincoln

69115

Investigational Site Number 276204, Heidelberg

70378

Investigational Site Number 276205, Stuttgart

72205

Investigational Site Number 840212, Little Rock

75231

Investigational Site Number 840258, Dallas

75246

Investigational Site Number 840201, Dallas

78731

Investigational Site Number 840203, Austin

85028

Investigational Site Number 840219, Phoenix

85050

Investigational Site Number 840227, Phoenix

89119

Investigational Site Number 840220, Las Vegas

89148

Investigational Site Number 840233, Las Vegas

90057

Investigational Site Number 840234, Los Angeles

90807

Investigational Site Number 840247, Long Beach

91325

Investigational Site Number 840235, Northridge

92020

Investigational Site Number 840241, El Cajon

92237

Investigational Site Number 276203, Sulzbach-Rosenberg

92262

Investigational Site Number 840251, Palm Springs

92591

Investigational Site Number 840223, Temecula

92648

Investigational Site Number 840231, Huntington Beach

92704

Investigational Site Number 840249, Santa Ana

92780

Investigational Site Number 840259, Tustin

93720

Investigational Site Number 840238, Fresno

94598

Investigational Site Number 840240, Walnut Creek

94904

Investigational Site Number 840229, Greenbrae

98055

Investigational Site Number 840222, Renton

190013

Investigational Site Number 643201, Saint Petersburg

194354

Investigational Site Number 643203, Saint Petersburg

194358

Investigational Site Number 643204, Saint Petersburg

195257

Investigational Site Number 643202, Saint Petersburg

300456

Investigational Site Number 642203, Timișoara

330084

Investigational Site Number 642204, Deva

400006

Investigational Site Number 642206, Cluj-Napoca

410030

Investigational Site Number 643205, Saratov

410159

Investigational Site Number 642205, Oradea

540142

Investigational Site Number 642207, Târgu Mureş

Investigational Site Number 642208, Târgu Mureş

550371

Investigational Site Number 642209, Sibiu

600154

Investigational Site Number 642210, Bacau

630004

Investigational Site Number 170203, Armenia

7500347

Investigational Site Number 152202, Santiago

Investigational Site Number 152204, Santiago

7500710

Investigational Site Number 152201, Santiago

Unknown

Investigational Site Number 840245, Chandler

Investigational Site Number 840224, Linden

Investigational Site Number 032205, Ciudad Autonoma de Buenos Aire

53209-0996

Investigational Site Number 840209, Milwaukee

C1425AGC

Investigational Site Number 032201, Caba

C1056ABJ

Investigational Site Number 032206, Capital Federal

C1179AAB

Investigational Site Number 032202, Capital Federal

00133

Investigational Site Number 380204, Roma

020042

Investigational Site Number 642201, Bucharest

Investigational Site Number 642202, Bucharest

110-746

Investigational Site Number 410202, Seoul

130-872

Investigational Site Number 410204, Seoul

139-872

Investigational Site Number 410205, Seoul

220-701

Investigational Site Number 410201, Wŏnju

08035

Investigational Site Number 724201, Barcelona

07010

Investigational Site Number 724202, Palma de Mallorca

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Sanofi

INDUSTRY