1,044
Participants
Start Date
April 17, 2015
Primary Completion Date
May 31, 2019
Study Completion Date
March 24, 2021
Cetuximab
500 mg/m\^2 via IV infusion on Day 1 of every 2-week cycle
FOLFOX induction regimen
Administered per the Investigator's discretion in accordance with locally approved prescribing information.
Fluoropyrimidine (5-FU/LV or capecitabine)
Per Investigator's discretion: 5-FU 1600-2400 mg/m\^2 administered via 46-hour IV infusion on Day 1 of every 2-week cycle and LV 400 mg/m\^2 administered via a 2-hour infusion on Day 1 every 2 weeks or 1000 mg/m\^2 twice-daily capecitabine (BID) by mouth given days 1-14 every 2 weeks. The chosen fluoropyrimidine should be administered in accordance with local prescribing information.
Atezolizumab
800 mg atezolizumab via 60-minute IV infusion on Day 1 of every 2-week cycle, or a fixed dose of 840 mg
Vemurafenib
960 mg vermurafenib BID by mouth
Bevacizumab
5 mg/kg bevacizumab via 15-30 minute IV infusion on Day 1 of every 2-week cycle per local prescribing information
Trastuzumab
Initial loading dose of 8 mg/kg followed by 6 mg/kg for subsequent doses by IV infusion on Day 1 of every 3-week treatment cycle
Pertuzumab
Initial fixed loading dose of 840 mg followed by 420 mg for subsequent doses by IV infusion on Day 1 of each 3-week treatment cycle
Cobimetinib
60 mg orally once daily for 3 weeks followed by a 1-week treatment break
5-FU/LV
1600-2400 mg/m\^2 5-FU via 46-hour IV infusion in combination with 400 mg/m\^2 LV via 2-hour infusion on Day 1 of every 2-week cycle until disease progression per the Investigator's assessment using modified Response Evaluation Criteria in Solid Tumors or death from any cause, whichever occurs first. The fluoropyrimidine should be administered in accordance with local prescribing information.
Capecitabine
1000 mg/m\^2 twice-daily capecitabine (BID) by mouth given days 1-14 every 2 weeks. The fluoropyrimidine should be administered in accordance with local prescribing information.
Institut Jules Bordet X, Brussels
Institute of Oncology Ljubljana, Ljubljana
Hospital Erasme, Brussels
Rigshospitalet; Onkologisk Klinik, København Ø
Herlev Hospital; Afdeling for Kræftbehandling, Herlev
UZ Leuven Gasthuisberg, Leuven
Hospital General Univ. de Alicante; Servicio de Oncologia, Alicante
CHC MontLégia, Liège
Sygehus Syd Roskilde; Onkologisk/haematologisk ambulatorium, Roskilde
Odense Universitetshospital, Onkologisk Afdeling R, Odense C
Regionshospitalet Gødstrup; Kræftafdelingen, Herning
AZ Delta (Campus Rumbeke), Roeselare
Onkologische Schwerpunktpraxis Kurfürstendamm, Berlin
Institute for Oncology and Radiology of Serbia; Clinic for Medical Oncology, Belgrade
National Cancer Institute, Cairo
DRK Kliniken Berlin Köpenick Darmzentrum, Berlin
Hospital Universitario Reina Sofia; Servicio de Oncologia, Córdoba
Instituto Nacional de Cancerologia; Oncology, Mexico City
Complejo Hospitalario Universitario de Santiago (CHUS) ; Servicio de Oncologia, Santiago de Compostela
Hospital de Donostia; Servicio de Oncologia Medica, Donostia / San Sebastian
Irccs Istituto Nazionale Dei Tumori (Int);S.C. Medicina Oncologica 1, Milan
Irccs Istituto Europeo Di Oncologia (IEO); Oncologia Medica, Milan
Asst Grande Ospedale Metropolitano Niguarda; Dipartimento Di Ematologia Ed Oncologia, Milan
Universitätsklinikum Hamburg-Eppendorf, Onkologisches Zentrum, Studienzentrale der II. Med. Klinik, Hamburg
MVZ für Hämatologie, Onkologie, Strahlentherapie und Palliativmedizin -; Klinik Dr. Hancken, Stade
Trakya University Medical Faculty Research And Practice Hospital Medical Oncology Department, Edirne
Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico; Servicio de Oncologia, Jaén
Humanitas Gavazzeni;U.O. Oncologia Medica, Bergamo
HOPITAL JEAN MINJOZ; Oncologie, Besançon
Hospital Universitari Arnau de Vilanova de Lleida; Servicio de Oncologia, Lleida
Ch De Montbeliard;Chir Generale Digestive, Montbéliard
Hospital General Universitario Gregorio Marañon; Servicio de Oncologia, Madrid
Hospital Ramon y Cajal; Servicio de Oncologia, Madrid
Hospital Universitario 12 de Octubre; Servicio de Oncologia, Madrid
Hospital Universitario La Paz; Servicio de Oncologia, Madrid
Hospital Universitario Puerta de Hierro; Servicio de Oncologia, Majadahonda
Hospital Regional Universitario Carlos Haya; Servicio de Oncologia, Málaga
Hopital Augustin Morvan; Federation De Cancerologie, Brest
Hopital Caremeau; Gastro Enterologie, Nîmes
Medizinische Hochschule Hannover; Zentrum Innere Medizin; Abt. Hämatologie u. Onkologie, Hanover
Hospital de Navarra; Servicio de Oncologia, Navarra
Hopital Rangueil; Gastro Enterologie Et Nutrition, Toulouse
Complejo Hospitalario de Orense; Servicio de Oncologia, Ourense
Hospital Univ. Central de Asturias; Servicio de Oncologia, Oviedo
Brüderkrankenhaus St. Josef, Paderborn
Hopital Haut Leveque, Pessac
Istanbul Uni Capa Medical Faculty; Inst. of Oncology, Istanbul
Marmara Uni Faculty of Medicine; Medical Oncology, Istanbul
Ege Uni Medical Faculty Hospital; Oncology Dept, Izmir
IRCCS Istituto Oncologico Veneto (IOV); Oncologia Medica Prima, Padua
Klinikum Wetzlar-Braunfels, Klinik für Hämatologie/Onkologie und Palliativmedizin, Wetzlar
Klinik Fulda, Medizinisches Versorgungszentrum Osthessen GmbH, Fulda
Fundacion Rodolfo Padilla Padilla A.C., León
A.O.U.I. VERONA-OSPEDALE POLICLINICO G.B. ROSSI BORGO ROMA;ONCOLOGIA MEDICA-d.U., Verona
Complejo Hospitalario Nuestra Señora de la Candelaria; Servicio de Oncologia, Santa Cruz de Tenerife
Hospital Universitario Marques de Valdecilla; Servicio de Oncologia, Santander
Onkologische Gemeinschaftspraxis, Magdeburg
Universitätsklinikum Magdeburg Klinik für Gastroenterologie und Hepatologie, Mageburg
Klinikum Magdeburg gGmbH Klinik für Allgemein- und Viszeralchirurgie, Magdeburg
Kliniken Maria Hilf GmbH, Krankenhaus St. Franziskus, Mönchengladbach
A.O. Universitaria Di Parma; Oncologia Medica, Parma
Klinik der Ruhr-Uni Bochum; Marien-Hospital Herne, Herne
Prosper-Hospital, Medizinische Klinik I, Recklinghausen
Hospital Clinico Universitario de Valencia; Servicio de Onco-hematologia, Valencia
Hospital General Universitario de Valencia; Servicio de oncologia, Valencia
Hospital Universitario la Fe; Servicio de Oncologia, Valencia
IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica, Meldola
Gemeinschaftspraxis für Hämatologie und Onkologie, Münster
Hospital Clinico Universitario Lozano Blesa; Servicio de Oncologia, Zaragoza
Hospital Universitario Miguel Servet; Servicio Oncologia, Zaragoza
Azienda Ospedaliero-Universitaria Careggi;S.C. Oncologia Medica 1, Florence
PIOH PD Dr. R. Schnell ? Dr. H. Schulz ? Dr. M. Hellmann, Frechen
Klinikum Mutterhaus der Borromaeerinnen gGmbH; Haematologie/Onkologie, Trier
Hopital Claude Huriez; Medecine Interne Oncologie, Lille
Krankenhaus Nordwest; Klinik f. Onkologie und Hämatologie, Frankfurt
Chu Estaing; Chir Generale Digestive A Et B, Clermont-Ferrand
Praxis für Hämatologie & Onkologie, Saarbrücken
Gemeinschaftspraxis für Hämatologie und Onkologie, PD Dr. Bauer, Dr. Thiel, Lebach
ICANS, Strasbourg
Oaxaca Site Management Organization, Oaxaca City
IRCCS Ospedale Casa Sollievo Della Sofferenza; Oncologia, San Giovanni Rotondo
Klinikum am Steinenberg / Ermstalklinik, Reutlingen
SLK-Kliniken Heilbronn GmbH; Klinik für Innere Medizin III; Schwerpunkt Häma./Onko./Palliativm., Heilbronn
Hopital Saint Antoine; Oncologie Medicale, Paris
Cancerologia de Queretaro; Oncologia, Queretaro, Queretaro
University Clinical Center of the Republic of Srpska, Banja Luka
IRCCS Istituto Nazionale Tumori Fondazione Pascale; Oncologia Medica A, Napoli
Städt. Klinikum München GmbH Klinikum Neuperlach Klinik f.Hämatologie u.Onkologie, München
Clinique Sainte Catherine, Avignon
Chu La Miletrie; Gastro Enterologie Endoscopies, Poitiers
Hämatologie Onkologie im Zentrum MVZ GmbH, Augsburg
Studienzentrum Onkologie Ravensburg GbR; Onkologie Ravensburg, Ravensburg
Hôpital Franco-Britannique- Fondation Cognacq-Jay; Cancerologie, Levallois-Perret
Krankenhaus Barmherziger Brüder; Klinik für Internistische Onkologie / Hämatologie, Regensburg
Institut Gustave Roussy; Departement Oncologie Medicale, Villejuif
Russian Oncology Research Center n.a. N.N. Blokhin Dpt of Clinical Pharmacology and Chemotherapy, Moscow
Bashkirian Republican Clinical Oncology Dispensary, Ufa
Hospital de Gastroenterologia Dr. Bonorino Udaondo ; Servicio de Oncología, Buenos Aires
Centro Oncologico Riojano Integral (CORI), La Rioja
Clínica Viedma, Viedma Rio Negro
Hospital da Cidade de Passo Fundo; Centro de Pesquisa em Oncologia, Passo Fundo
Hospital das Clinicas - UFRGS, Porto Alegre
Hospital Nossa Senhora da Conceicao, Porto Alegre
Hospital de Cancer de Barretos, Barretos
Hospital Amaral Carvalho, Jaú
Faculdade de Medicina de Sao Jose do Rio Preto - FAMERP*X*, São José do Rio Preto
Instituto de Ensino e Pesquisa Sao Lucas - IEP, São Paulo
Ain Shams University Hospital; Oncology, Cairo
BAG Freiberg-Richter, Jacobasch, Illmer, Wolf; Gemeinschaftspraxis Hämatologie-Onkologie, Dresden
Agioi Anargyroi; 3Rd Dept. of Medical Oncology, Athens
Univ General Hosp Heraklion; Medical Oncology, Heraklion
Uni Hospital of Ioannina; Oncology Dept., Ioannina
University Hospital of Patras Medical Oncology, Pátrai
Thermi Clinic; Oncology Clinic, Thermi Thessalonikis
Bioclinic Thessaloniki, Thessaloniki
Euromedical General Clinic of Thessaloniki; Oncology Department, Thessaloniki
Istituto Regina Elena; Oncologia Medica A, Rome
"Policlinico Universitario Agostino Gemelli; U.O.C. Oncologia Medica", Rome
Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
Ijsselland Ziekenhuis; Inwendige Geneeskunde, Capelle aan den IJssel
Deventer Ziekenhuis; Interne Geneeskunde, Deventer
Albert Schweitzer Ziekenhuis - loc Dordrecht, Dordrecht
Catharina ZKHS; Inwendige Geneeskunde Afd., Eindhoven
St. Antonius locatie Leidsche Rijn, Utrecht
Isala Klinieken, Zwolle
Szpital Uniwersytecki w Krakowie, Oddzia? Kliniczny Kliniki Onkologii, Krakow
Narodowy Instytut Onkologii im. M. Sklodowskiej-Curie; Klinika Onkologii i Radioterapii,, Warsaw
HUC; Servico de Oncologia Medica, Coimbra
Hospital de Santa Maria; Servico de Oncologia Medica, Lisbon
Narodny Onkologicky Ustav; Oddelenie klinickej onkologie E, Bratislava
POKO Poprad; Department of Oncology, Poprad
Seoul National University Hospital, Seoul
Severance Hospital, Yonsei University Health System, Seoul
Asan Medical Center, Seoul
Samsung Medical Center, Seoul
Hospital General Universitario de Elche; Servicio de Oncologia, Elche
Hospital Universitario Son Espases, Palma de Mallorca
Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia, Badalona
Hospital Univ Vall d'Hebron; Servicio de Oncologia, Sant Andreu de la Barca
Skånes University Hospital, Skånes Department of Onclology, Lund
Karolinska Hospital; Oncology - Radiumhemmet, Stockholm
Acibadem University School of Medicine, Adana Hospital; General Surgery, Adana
Hacettepe Uni Medical Faculty Hospital; Oncology Dept, Sihhiye/Ankara
Aberdeen Royal Infirmary; Medical Oncology Dept, Aberdeen
Birmingham Heartlands Hospital, Birmingham
Broomfield Hospital; Oncology, Chelsmford
Castle Hill Hospital; The Queens Centre for Oncology and Haematology, Cottingham
Guys and St Thomas NHS Foundation Trust, Guys Hospital, London
Royal Marsden Hospital; Dept of Med-Onc, London
Christie Hospital Nhs Trust; Medical Oncology, Manchester
Mount Vernon Hospital, Middlesex
Queen's Hospital, Romford
Southampton General Hospital; Medical Oncology, Southampton
Royal Marsden Hospital; Dept. of Medicine, Sutton
Hoffmann-La Roche
INDUSTRY