Cyclin D1 Based TPF Induction Chemotherapy for Oral Squamous Cell Carcinoma Patients at Clinical N2 Stage

PHASE2RecruitingINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

December 31, 2016

Primary Completion Date

December 31, 2024

Study Completion Date

December 31, 2026

Conditions
Mouth NeoplasmsCarcinoma, Squamous Cell
Interventions
DRUG

TPF group

"The patients in the experimental group received the TPF induction chemotherapy for 2 cycles followed by radical surgery and post-operative radiotherapy.~docetaxel:75mg/m2 cisplatin:75 mg/m2 5-Fu:750 mg/m2/day"

PROCEDURE

surgery group

The patients in the control group received the radical surgery and post-operative radiotherapy.

RADIATION

Post-operative radiotherapy

Radiotherapy was arranged 4 to 6 weeks after surgery. Routine external beam radiotherapy, such as conformal or intensity modulated radiotherapy was performed, and the dose was 1.8-2 Gy/day, 5 days/week for 6 weeks, and totally 54-60 Gy.

Trial Locations (1)

200011

RECRUITING

Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai

All Listed Sponsors
lead

Shanghai Jiao Tong University School of Medicine

OTHER