Dose Escalation and Double-blind Study of Veliparib in Combination With Carboplatin and Etoposide in Treatment-naive Extensive Stage Disease Small Cell Lung Cancer

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

221

Participants

Timeline

Start Date

October 13, 2014

Primary Completion Date

April 17, 2019

Study Completion Date

April 17, 2019

Conditions
Small Cell Lung Cancer
Interventions
DRUG

Veliparib

Capsules administered orally twice a day according to the dosing schedule.

DRUG

Carboplatin

Administered by intravenous infusion on Day 1 of each 21-day cycle over approximately 30 minutes at a target area under the curve (AUC) 5 mg/mL\*minute.

DRUG

Etoposide

Administered by intravenous infusion on Days 1 to 3 of every 21-day cycle over approximately 60 minutes at 100 mg/m².

DRUG

Placebo

Placebo to veliparib administered orally twice a day according to the dosing schedule.

Trial Locations (62)

1122

Orszagos Koranyi Pulmonologiai Intezet /ID# 151351, Budapest XII

1200

Cliniques Universitaires Saint Luc /ID# 151024, Woluwe-Saint-Lambert

2500

Southern Medical Day Care Ctr /ID# 155498, Wollongong

2650

UZ Antwerp /ID# 151026, Edegem

3199

Peninsula & South Eastern Haem /ID# 155497, Frankston

3233

Matrahaza Gyogyintezet /ID# 151355, Kékesteto

3690

Border Medical /ID# 157894, Wodonga

4000

CHU de Liege /ID# 151025, Liège

4032

Debreceni Egyetem Klinikai Központ /ID# 151354, Debrecen

4814

The Townsville Hospital /ID# 155499, Douglas

5000

CHU UCL Namur /ID# 151022, Namur

5004

Jasz-Nagykun-Szolnok Megyei /ID# 155090, Szolnok

7000

C.H.U.de Mons Borinage /ID# 151023, Mons

8000

Fejer Megyei Szent Gyorgy Korh /ID# 151352, Székesfehérvár

8582

Veszprem Megyei Tudogyogyintez /ID# 158807, Farkasgyepű

9023

Petz Aladar Megyei Oktato Korh /ID# 155352, Győr

9700

Markusovszky Egyetemi Oktatókórház /ID# 158806, Szombathely

15212

Allegheny General Hospital /ID# 147328, Pittsburgh

28009

Hospital Universitario Gregori /ID# 164982, Madrid

28041

Hosp Univ 12 de Octubre /ID# 151252, Madrid

28050

Hosp Univ Madrid Sanchinarro /ID# 130301, Madrid

28222

Hosp Univ Puerta de Hierro Maj /ID# 151253, Majadahonda

30322

Emory University Hospital /ID# 141682, Atlanta

30912

Georgia Regents University /ID# 148567, Augusta

44718

Gabrail Cancer Center Research /ID# 129216, Canton

48912

Herbert Herman Cancer Center /ID# 167020, Lansing

49201

Dong-A University Hospital /ID# 153187, Busan

58128

Chonnam National University Hwasun Hospital /ID# 153188, Jeonnam

72037

Centre Hospitalier Le Mans /ID# 158103, Le Mans

77030

University of Texas MD Anderson Cancer Center /ID# 129213, Houston

80045

Univ of Colorado Cancer Center /ID# 129220, Aurora

85259

Mayo Clinic - Scottsdale /ID# 129127, Scottsdale

87042

CHU Dupuytren /ID# 153622, Limoges

94000

Centre Hosp Intercommunal de Creteil /ID# 157970, Créteil

109028

Univercity Headache Clynic,LTD /ID# 161708, Moscow

115478

NN Blokhin Russian Cancer /ID# 152329, Moscow

183047

Murmansk RCH P.A. Bayandina /ID# 152331, Murmansk

195271

Road Hospital Open Joint Stock Company Russian Railways /ID# 152731, Saint Petersburg

200347

S.C. Centrul de Oncologie Sf. Nectarie S.R.L. /ID# 161137, Craiova

300166

Oncocenter Oncologie Clinica S /ID# 151694, Timișoara

308001

Belgorod Oncology Dispensary /ID# 152330, Belgorod

407280

S.C. Radiotherapy Center Cluj /ID# 165137, Cluj-Napoca

430005

Ogarev Mordovia State Univ /ID# 152327, Saransk

620043

Sverdlovsk Regional Oncology Center Dispensary /ID# 152328, Yekaterinburg

60611-2927

Northwestern University Feinberg School of Medicine /ID# 137088, Chicago

T2N 4Z6

University of Calgary /ID# 152544, Calgary

T6G 1Z2

Cross Cancer Institute /ID# 132883, Edmonton

L8V 1C3

Juravinski Cancer Clinic /ID# 152543, Hamilton

H4J 1C5

Hopital du Sacre Coeur Montreal /ID# 154436, Montreal

262 04

Nemocnice Na Plesi s.r.o. /ID# 149825, Nová Ves pod Pleší

741 01

Nemocnice Novy Jicin /ID# 149838, Nový Jičín

703 84

Vitkovicka nemocnice a. s. /ID# 149839, Ostrava

530-03

Multiscan s.r.o. /ID# 150887, Pardubice

9713 GZ

Universitair Medisch Centrum Groningen /ID# 131252, Groningen

3844 DG

Ziekenhuis St. Jansdal /ID# 151974, Harderwijk

6419 PC

Atrium-Orbis Zuyderland Medisch Centrum /ID# 149830, Heerlen

3015 CE

Erasmus Medisch Centrum /ID# 131251, Rotterdam

8025 AB

Isala /ID# 151975, Zwolle

361-240

Chungbuk National Univ Hosp /ID# 153186, Cheongju-si

05505

Asan Medical Center /ID# 153185, Seoul

08025

Hospital Stanta Creu i Sant Pau /ID# 151254, Barcelona

08028

Hosp Univ Quiron Dexues /ID# 130302, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AbbVie

INDUSTRY