Tandem Melphalan and Autolog. SCT in MM Patients 60 to 70 Years of Age With and Without Induction Chemotherapy

4 cycles of anthracycline/dexamethasone-based chemotherapy

2 x 4 days of dexamethasone (day 1-4 and day 8-11: 40mg)

Ifosfamide (day 1-3: 1.900mg/m² iv), epirubicin (day 1: 75 mg/m² iv), etoposide (day 1-3: 120 mg/m² iv) and G-CSF (day 5 until end of apheresis: 5µg/kg sc)

stem cell apheresis in peripheral blood, sought amount of CD34-cells: 6 \* 10E6/kg

Two cycles of high-dose melphalan (day -3 and day -2: 70mg/m²)

Two infusions of collected stem cells (day 0: 2\*10E6 CD34-cell/kg per transplantation)