Exploratory Evaluation of AR-42 Histone Deacetylase Inhibitor in the Treatment of Vestibular Schwannoma and Meningioma

EARLY_PHASE1TerminatedINTERVENTIONAL
Enrollment

7

Participants

Timeline

Start Date

December 31, 2015

Primary Completion Date

May 30, 2017

Study Completion Date

January 4, 2021

Conditions
Vestibular SchwannomaMeningiomaAcoustic NeuromaNeurofibromatosis Type 2
Interventions
DRUG

AR-42

AR-42 will be administered in a total of ten oral doses, +/- 1 dose, at 40 mg/dose, will be self-administered by study participants at approximately 8:00pm (+/- 1 hour) for 3 weeks pre-operatively, with the last dose being administered the night before surgery. The treating surgeon will perform the clinically indicated surgical procedure 3 weeks post-initial dose of medication as well as the specimen collection.

Trial Locations (4)

21287

Johns Hopkins University, Baltimore

55905

Mayo Clinic, Rochester

94305

Stanford University, Stanford

02214

Massachusetts Eye and Ear, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Johns Hopkins University

OTHER

collaborator

Mayo Clinic

OTHER

collaborator

Stanford University

OTHER

collaborator

Ohio State University

OTHER

collaborator

Nationwide Children's Hospital

OTHER

lead

Massachusetts Eye and Ear Infirmary

OTHER