Safety/Efficacy of MEDI-551 in Combination With Immunomodulating Therapies in Subjects With Aggressive B-cell Lymphomas

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

December 1, 2014

Primary Completion Date

May 24, 2016

Study Completion Date

May 24, 2016

Conditions
Relapsed/Refractory Aggressive B-cell Lymphomas
Interventions
DRUG

MEDI-551 12 mg/kg

Participants will receive intravenous (IV) infusion of MEDI-551 12 mg/kg on Days 1 and 8 of Cycle 1 and Day 1 of Cycle 2 through Cycle 13

DRUG

MEDI0680 2.5 mg/kg

Participants will receive IV infusion of MEDI0680 2.5 mg/kg on Days 2 and 15 of Cycle 1 and Days 1 and 15 of Cycle 2 through Cycle 13.

DRUG

MEDI0680 10 mg/kg

Participants will receive IV infusion of MEDI0680 10 mg/kg on Days 2 and 15 of Cycle 1 and Days 1 and 15 of Cycle 2 through Cycle 13.

Trial Locations (6)

10467

Research Site, The Bronx

21231

Research Site, Baltimore

44195

Research Site, Cleveland

53226

Research Site, Milwaukee

63110

Research Site, St Louis

36294-3300

Research Site, Birmingham

Sponsors

Lead Sponsor

All Listed Sponsors
lead

MedImmune LLC

INDUSTRY