An Open-Label Study of a Novel JAK-inhibitor, INCB052793, Given to Patients With Advanced Malignancies

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

83

Participants

Timeline

Start Date

September 10, 2014

Primary Completion Date

February 27, 2019

Study Completion Date

February 27, 2019

Conditions
Solid TumorsAdvanced MalignanciesMetastatic Cancer
Interventions
DRUG

INCB052793

Initial cohort dose of INCB052793 monotherapy at the protocol-specified starting dose, with subsequent cohort escalations based on protocol-specific criteria.

DRUG

gemcitabine

Gemcitabine administered intravenously over 30 minutes at the protocol-specified dose and frequency.

DRUG

nab-paclitaxel

nab-paclitaxel administered intravenously over 30 minutes at the protocol-specified dose and frequency.

DRUG

dexamethasone

Dexamethasone administered orally at the protocol-specified dose and frequency.

DRUG

Carfilzomib

Carfilzomib administered intravenously at the protocol-specified dose and frequency.

DRUG

bortezomib

Bortezomib administered intravenously or subcutaneously at the protocol-specified dose and frequency.

DRUG

lenalidomide

Lenalidomide administered orally at the protocol-specified dose and frequency.

DRUG

azacitidine

Azacitidine administered subcutaneously at the protocol-specified dose and frequency.

DRUG

INCB052793

INCB052793 tablets administered orally at the protocol specified dose strength and frequency.

DRUG

pomalidomide

Pomalidomide administered orally at the protocol-specified dose and frequency.

DRUG

INCB050465

INCB050465 tablets administered orally at the protocol specified dose strength and frequency.

DRUG

INCB039110

INCB039110 tablets administered orally at the protocol specified dose strength and frequency.

Trial Locations (14)

Unknown

Birmingham

West Hollywood

New Haven

Atlanta

Chicago

Indianapolis

Hackensack

New York

Durham

Portland

Greenville

Site 2, Nashville

Nashville

Dallas

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Incyte Corporation

INDUSTRY