Immune Function and Muscle Adaptations to Resistance Exercise in Older Adults

NACompletedINTERVENTIONAL
Enrollment

59

Participants

Timeline

Start Date

July 23, 2014

Primary Completion Date

December 31, 2018

Study Completion Date

September 30, 2019

Conditions
SarcopeniaAgingImmune Function
Interventions
BIOLOGICAL

TDAP

Both arms will receive the tetanus, diptheria, and pertussis vaccination after two weeks of treatment with supplement or placebo

OTHER

Acute Resistance Exercise

Both arms will receive a single bout of resistance exercise twice, before and after two weeks of treatment with supplement or placebo, and be evaluated for the response within blood and muscle

OTHER

Resistance Exercise Training

Both arms will receive 36 sessions of progressive high-intensity resistance exercise training (thigh muscle) over the course of approximately 12 weeks.

OTHER

Post-training Follow-up

Both arms will continue to receive treatment with supplement or placebo for approximately 26 weeks after completion of the exercise training. During this time subjects will not be allowed to perform resistance exercise.

DIETARY_SUPPLEMENT

Nutritional Supplement (Muscle Armor)

Subjects in the supplement group will consume orange-flavored Muscle Armor according to the manufacturer's directions: one serving (approximately 30g, i.e. one scoop provided with the product by its manufacturer), twice daily mixed with 12 ounces (oz) of water beginning after all baseline assessments are performed including assessment of the response to acute exercise and continuing until the end of study participation.

DIETARY_SUPPLEMENT

Placebo (Kool-Aid)

Subjects in the placebo group will consume orange-flavored Kool-Aid (Kraft Foods) according to the manufacturer's directions: one serving (approximately 13g, i.e. one scoop provided with the product by the pharmacy), twice daily mixed with 12 ounces (oz) of water beginning after all baseline assessments are performed including assessment of the response to acute exercise and continuing until the end of study participation.

Trial Locations (1)

72114-1706

Central Arkansas Veterans Healthcare System Eugene J. Towbin Healthcare Center, Little Rock, AR, North Little Rock

All Listed Sponsors
collaborator

University of Arkansas

OTHER

lead

VA Office of Research and Development

FED

NCT02261961 - Immune Function and Muscle Adaptations to Resistance Exercise in Older Adults | Biotech Hunter | Biotech Hunter