331
Participants
Start Date
October 15, 2014
Primary Completion Date
October 21, 2021
Study Completion Date
October 21, 2021
Bendamustine
Bendamustine 90 milligrams per meter-squared (mg/m\^2) per day administered IV on Days 2 and 3 of Cycle 1, then on Days 1 and 2 of each subsequent cycle for up to 6 cycles (each cycle is 21 days in DLBCL and 28 days in FL).
Obinutuzumab
Obinutuzumab 1000 milligrams (mg) IV on Days 1, 8, and 15 of Cycle 1 and on Day 1 of each subsequent cycle for up to 6 cycles (each cycle is 21 days in DLBCL and 28 days in FL).
Polatuzumab vedotin (Liquid)
Polatuzumab vedotin 1.8 milligrams per kilogram (mg/kg) administered IV on Day 2 of Cycle 1, then on Day 1 of each subsequent cycle for up to 6 cycles (each cycle is 21 days in DLBCL and 28 days in FL).
Rituximab
Rituximab standard dose, 375 mg/m\^2 IV on Day 1 of each cycle for up to 6 cycles (each cycle is 21 days in DLBCL and 28 days in FL).
Polatuzumab vedotin (Lyophilized)
Participants in the New Formulation (NF) Cohort (Arms G and H) will follow the same schedule and dosing requirements as participants in the other Phase II cohorts (Arms A-F).
Semmelweis University, First Dept of Medicine, Budapest
National Institute of Oncology, A Dept of Internal Medicine, Budapest
Prince of Wales Hospital; Oncology, Randwick
Monash Medical Centre; Haematology Research, Clayton
University of Debrecen Medical and Health Science Center, Institute of Internal medicine Building B, Debrecen
Royal Adelaide Hospital, Adelaide
Adelaide Cancer Centre, Kurralta Park
Memorial Sloan Kettering Cancer Center, New York
Ospedale Civile SS. Antonio E Biagio DI Alessandria; Ematologia, Alessandria
Irccs Istituto Europeo Di Oncologia (IEO); Emato-Oncologia, Milan
Chu Site Du Bocage;Hematologie Clinique, Dijon
Weinberg CA Inst Franklin Sq, Baltimore
A.O. Spedali Civili Di Brescia-P.O. Spedali Civili;U.O. Ematologia, Brescia
Hospital Universitario la Paz; Servicio de Hematologia, Madrid
Levine Cancer Institute, Charlotte
Emory Univ Winship Cancer Inst, Atlanta
Cancer Specialists; North Florida ;Jacksonville (AC Skinner Pkwy), Jacksonville
Joh. Wesling Klinikum Minden; Klinik fuer Hämatologie und Onkologie, Minden
CHU Saint Eloi; Service d'Hématologie Clinique, Montpellier
Dokuz Eylul Uni ; Hematology, Izmir
Clearview Cancer Institute, Huntsville
Hospital Clinico Universitario de Salamanca;Servicio de Hematologia, Salamanca
West Clinic, Germantown
Hospital Universitario Virgen del Rocio; Servicio de Hematologia, Seville
Horizon Oncology Research, Inc., Lafayette
Gemeinschaftspraxis für Hämatologie und Onkologie, Münster
Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Abt. für Hämatologie und Onkologie, Mainz
Ondokuzmayis University Medical Faculty Heamatology Department, Samsun
Joliet Oncology-Hematology; Associates, Ltd., Joliet
Karadeniz Technical Uni School of Medicine; Hematology, Trabzon
CHU Lyon Sud - Service Hématologie, Pierre-Bénite
Centre Leon Berard; Departement Oncologie Medicale, Lyon
Fakultní nemocnice Ostrava Klinika hematoonkologie, Ostrava
Centre Henri Becquerel; Hematologie, Rouen
Univ of Colorado Canc Ctr, Aurora
Istituto Nazionale Tumori Irccs Fondazione g. Pascale;s.c. Ematologia Oncologica, Napoli
Centre Hospitalier Departemental Les Oudairies, La Roche-sur-Yon
University of New Mexico Cancer Center, Albuquerque
City of Hope National Medical Center, Duarte
Klinik der Uni Regensburg; Hämatologie/Onkologie, Studienzentrale, Regensburg
Swedish Cancer Inst., Seattle
Northwest Medical Specialties, Tacoma
HELIOS Klinikum Erfurt - Innere Medizin - 4. Medizinische Klinik, Hämatologie, Erfurt
University of Alabama at Birmingham, Birmingham
Regional Cancer Care Associates LLC - Morristown, Morristown
BCCA-Vancouver Cancer Centre, Vancouver
Queen Elizabeth II Health Sciences Centre; Oncology, Halifax
Hopital Maisonneuve- Rosemont; Oncology, Montreal
Jewish General Hospital, Montreal
Fakultni nemocnice Brno; Interni hematologicka a onkologicka klinika, Brno
Fakultni nemocnice Hradec Kralove, Hradec Králové
I Interni klinika; Vseobecna fakultni nemocnice, Prague
UMC St. Radboud; Hematology, Nijmegen
Seoul National University Hospital, Seoul
Samsung Medical Center, Seoul
Hospital Universitari Vall d'Hebron; Servicio de Hematologia, Barcelona
Hospital Clinic i Provincial de Barcelona; Hematology, Barcelona
Ankara University; Hematology, Ankara
KINGS COLLEGE HOSPITAL; Commercial R&D Amendments, Kings Health Partners Clinical Trials Office, London
Christie Hospital Nhs Trust; Medical Oncology, Manchester
Nottingham City Hospital; Dept of Haematology, Nottingham
Southampton General Hospital; Somers Cancer Research Building, Southampton
Hoffmann-La Roche
INDUSTRY