Extended Infusion Carfilzomib on a Weekly Schedule in Patients With Advanced Solid Tumors

Carfilzomib will be given as an IV infusion over 4 hours. Subjects will remain at the clinic under observation for at least 1 hour following each dose of carfilzomib in Cycle 1 and following the dose on Cycle 2 Day 1. During these observation times, post dose IV hydration may be given at physician's discretion.

Dexamethasone 8 mg PO/IV will be administered prior to all carfilzomib doses.