Lenalidomide in Combination With Microtransplantation as Post-remission Therapy in AML

PHASE1TerminatedINTERVENTIONAL
Enrollment

8

Participants

Timeline

Start Date

January 31, 2015

Primary Completion Date

December 31, 2016

Study Completion Date

December 31, 2016

Conditions
Acute Myeloid Leukemia (AML)Acute Myelocytic LeukemiaAcute Myelogenous LeukemiaAcute Granulocytic LeukemiaAcute Non-Lymphocytic Leukemia
Interventions
DRUG

Lenalidomide

Patients will receive lenalidomide starting on day 6 of each post-remission cycle, following conclusion of cytarabine post-remission therapy on days 1-5. Following count recovery in the third post-remission cycle, patients will then receive lenalidomide daily as a maintenance therapy.

GENETIC

HLA-mismatched stem-cell Microtransplantation

Patient will receive HLA-mismatched stem cell microtransplant infusion on day 6 of each post-remission cycle, following conclusion of course of cytarabine in each cycle.

DRUG

Cytarabine

Patients will receive cytarabine post-remission therapy for 3 cycles, on days 1-5 of each cycle.

Trial Locations (1)

02114

Massachusetts General Hospital, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Celgene Corporation

INDUSTRY

lead

Massachusetts General Hospital

OTHER