The Effect of BI 187004 on the Pharmacokinetics of Cytochrome P450 Substrates (Caffeine, Warfarin, Omeprazole, Metoprolol and Midazolam) and a P Glycoprotein Substrate (Digoxin)

single dose of midazolam given as oral solution (day 1 of visits 2 and 3)

single dose of caffeine given as tablets (day 1 of visits 2 and 3)

single dose of digoxin given as tablets (day 3 of visits 2 and 3)

single dose of warfarin given as tablets (day 1 of visits 2 and 3)

single dose of omeprazole given as tablet (day 1 of visits 2 and 3)

multiple doses of BI 187004 given as tablets (day 7-12 of visit 2 and day 1-6 of visit 3)

single dose of metoprolol given as tablets (day 1 of visits 2 and 3)