A Study of Nonsteroidal Aromatase Inhibitors Plus Abemaciclib (LY2835219) in Postmenopausal Women With Breast Cancer

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

493

Participants

Timeline

Start Date

November 6, 2014

Primary Completion Date

January 31, 2017

Study Completion Date

December 31, 2025

Conditions
Breast Cancer
Interventions
DRUG

Abemaciclib

Administered orally

DRUG

Anastrozole

Administered orally

DRUG

Letrozole

Administered orally

DRUG

Placebo

Administered orally

Trial Locations (155)

100

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Taipei

112

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Beidou

235

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Zhonghe

1023

Auckland City Hospital, Auckland

1070

Institut Jules Bordet, Anderlecht

1090

Medizinische Universität Wien, Vienna

Universitaetsklinikum Allgemeines Krankenhaus Wien, Vienna

1200

Cliniques universitaires Saint-Luc, Brussels

2010

St Vincent's Hospital, Sydney

2050

Chris O'Brien Lifehouse, Camperdown

2076

Sydney Adventist Hospital, Wahroonga

2610

Iridium Kankernetwerk Wilrijk en Antwerp, Wilrijk

2990

Hospital La Raza, Mexico City

3080

Seoul National University Hospital, Seoul

3220

Barwon Health - The Geelong Hospital, Geelong

3310

Grupo Medico Camino Sc, Mexico City

3722

Severance Hospital, Yonsei University Health System, Seoul

4020

Ordensklinikum Linz, Linz

4101

Mater Adult Hospital Brisbane, South Brisbane

4102

Princess Alexandra Hospital, Woolloongabba

5000

CHU UCL Namur/Site Sainte Elisabeth, Namur

5011

The Queen Elizabeth Hospital, Woodville

5505

Asan Medical Center, Seoul

6000

Grand Hopital de Charleroi-Site Notre-Dame, Charleroi

6020

Medizinische Universitaet Innsbruck, Innsbruck

6150

St. John of God Murdoch Hospital, Murdoch

6351

Samsung Medical Center, Seoul

8036

Medizinische Universitaet Graz, Graz

8800

AZ Delta, Roeselare

10011

Mount Sinai Cancer Center, New York

10060

Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia, Candiolo

10408

National Cancer Center, Goyang-si

11528

Alexandra Hospital, Athens

13620

Seoul National University Bundang Hospital, Seongnam

16132

Ospedale San Martino, Genoa

20014

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Donostia / San Sebastian

20249

Facharztzentrum Eppendorf, Hamburg

21079

Centre Georges François Leclerc, Dijon

22027

Centre Hospitalier de Saint-Brieuc - Hôpital Yves Le Foll, Saint-Brieuc

22087

Kath. Marienkrankenhaus gGmbH, Hamburg

22332

Inha University Hospital, Incheon

22770

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Edirne

23562

Lübecker Onkologische Schwerpunktpraxis, Lübeck

24127

Azienda Ospedaliera Papa Giovanni XXIII, Bergamo

25030

CHU de Besancon Hopital Jean Minjoz, Besançon

25198

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Lleida

27000

Clinica Oncológica San Francisco, Torreón

28007

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Madrid

29200

Centre Hospitalier Régional Universitaire de Brest - Hôpital Morvan, Brest

31404

Candler Medical Oncology Practice - Statesboro, Savannah

31405

Candler Medical Oncology Practice - Statesboro, Savannah

33077

Polyclinique Bordeaux Nord, Bordeaux

33104

Lakes Research, LLC, Miami Lakes

33305

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Kuei Shan Hsiang

33308

Holy Cross Hospital, Fort Lauderdale

34070

Centre de Cancérologie du Grand Montpellier, Montpellier

37000

Fundacion Rodolfo Padilla AC, León

37024

Ospedale Sacro Cuore Don G. Calabria, Negrar Di Valpolicella

37920

University of Tennessee Medical Center, Knoxville

40139

Ospedale Bellaria - Azienda USL di Bologna, Bologna

40447

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Taichung

40479

Marien-Hospital Düsseldorf, Düsseldorf

41404

Kyungpook National University Chilgok Hospital, Daegu

44033

Ulsan University Hospital, Ulsan

44124

Azienda Ospedaliero Universitaria di Ferrara, Cona

44280

Hospital Civil Fray Antonio Alcalde, Guadalajara

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Malatya

44805

Institut de Cancérologie de l'Ouest, Saint-Herblain

46015

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Valencia

49100

Rabin Medical Center, Petah Tikva

54100

Polyclinique de Gentilly, Nancy

55905

Mayo Clinic in Rochester, Minnesota, Rochester

59100

Nuovo Ospedale di Prato-S.Stefano, Prato

62290

Centro Oncologico Belenus, Cuernavaca

65199

Helios Dr. Horst Schmidt Kliniken, Wiesbaden

68506

Nebraska Hematology-Oncology, P.C., Lincoln

69008

Centre Leon Berard, Lyon

70020

Centro de Estudios Y Prevencion Del Cancer, Juchitán de Zaragoza

70185

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Örebro

71640

Klinikum Ludwigsburg, Ludwigsburg

72100

Ospedale Perrino, Brindisi

72762

Highlands Oncology Group, Springdale

76090

Cancerología, Colinas Del Cimatario

77030

Oncology Consultants P.A., Houston

79410

Joe Arrington Cancer Center, Lubbock

80187

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Gävle

81675

Klinikum Rechts der Isar der TU München, München

85000

CHD Vendee, La Roche-sur-Yon

85224

Ironwood Cancer & Research Centers, Chandler

89075

Universitätsklinikum Ulm, Ulm

89169

Comprehensive Cancer Centers of Nevada, Las Vegas

90024

TRIO-US (Translational Research in Oncology-US), Los Angeles

90095

Central Coast Medical Oncology Corporation, Los Angeles

Orlando Health, Inc, Los Angeles

90404

UCLA Hematology/Oncology - Parkside, Santa Monica

93309

CBCC Global Research, Inc., Bakersfield

93720

California Cancer Associates Research and Excellence, Fresno

95817

North Valley Hematology/Oncology Medical Group, Los Angeles

98158

Azienda Ospedaliera Ospedali Riuniti Papardo Piemonte, Messina

115478

"Fed State Budgetary Inst N.N. Blokhin Med Center of Oncology MHRF", Moscow

129090

European Medical Center, Moscow

163045

Arkhangelsk Clinical Oncological Dispensary, Arkhangelsk

190013

Clinic Complex, Saint Petersburg

197022

Saint-Petersburg City Clinical Oncology Dispensary, Saint Petersburg

197758

Rosmedtech Scientific Research Institute of Oncology, Saint Petersburg

420029

Republic Oncology Dispensary of MoH of Republic Tatarstan, Kaznan

2418515

Kanagawa cancer center, Yokohama

3109601

Rambam Health Care Campus, Haifa

4428164

Meir Medical Center, Kfar Saba

5265601

Sheba Medical Center, Ramat Gan

6423906

Tel Aviv Sourasky Medical Center, Tel Aviv

7610001

Kaplan Medical Center, Rehovot

8410101

Soroka Medical Center, Beersheba

9112001

Hadassah Medical Center, Jerusalem

T6G 1Z2

Cross Cancer Institute, Edmonton

L1G 2B9

Lakeridge Health, Oshawa

K1H 8L6

The Ottawa Hospital - General Campus, Ottawa

M5G 2M9

Princess Margaret Hospital (Ontario), Toronto

H2L 4M1

Hopital Notre Dame, Montreal

H3T 1E2

Jewish General Hospital, Montreal

H4J 1C5

Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de-Montréal (CIUSSS NÎM) - H -T, Montreal

G1S 4L8

Hopital du Saint-Sacrement, Québec

00189

Policlinico Ospedale S. Andrea, Roma

05100

Azienda Ospedaliera Santa Maria Terni, Terni

464-8681

Aichi Cancer Center Hospital, Nagoya

260-8717

Chiba cancer center, Chiba

791-0280

National Hospital Organization Shikoku Cancer Center, Matsuyama

003-0804

National Hospital Organization Hokkaido Cancer Center, Sapporo

663-8501

Hyogo College of Medicine, Nishinomiya

951-8566

Niigata Cancer Center Hospital, Niigata

589-8511

Kindai University Hospital- Osakasayama Campus, Ōsaka-sayama

362-0806

Saitama Prefectural Cancer Center, Kitaadachi-Gun

411-8777

Shizuoka Cancer Center, Nakatogari

329- 0498

Jichi Medical University Hospital, Shimotsuke

113-8677

Tokyo Met Cancer & Infectious Diseases Center Komagome Hp, Bunkyo-ku

135-8550

Japanese Foundation for Cancer Research, Koto

160-0023

Tokyo Medical University Hospital, Shinjuku-ku

811-1395

National Hospital Organization Kyushu Cancer Center, Fukuoka

730-8518

Hiroshima City Hospital, Hiroshima

606-8507

Kyoto University Hospital, Kyoto

540-0006

National Hospital Organization Osaka Medical Center, Osaka

541-8567

Osaka International Cancer Institute, Osaka

06760

Superare Centro de Infusion, México

2545 AA

Haga Ziekenhuis locatie Leyweg, The Hague

2333 ZA

Leids Universitair Medisch Centrum, Leiden

812 50

Onkologicky Ustav sv. Alzbety, Bratislava

041-90

Vychodoslovensky Onkologicky ustav a.s., Košice

06080

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Badajoz

08907

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Barcelona

SE-72189

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Västerås

06100

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Ankara

CH63 4JY

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Bebbington

CB20QQ

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Cambridge

M20 4BX

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Manchester

SM2 5PT

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Sutton

All Listed Sponsors
lead

Eli Lilly and Company

INDUSTRY

NCT02246621 - A Study of Nonsteroidal Aromatase Inhibitors Plus Abemaciclib (LY2835219) in Postmenopausal Women With Breast Cancer | Biotech Hunter | Biotech Hunter