Perifosine and Torisel (Temsirolimus) for Recurrent/Progressive Malignant Gliomas

Standard of care/routine cytoreductive glioma resection surgery. Arm B only.

Perifosine is a pill that has not been approved by the FDA which blocks a messenger that tells cancer cells to grow.

Temsirolimus is an intravenous drug approved by the FDA for treatment of other cancers (kidney cancer, certain types of lymphoma) but not for brain tumors.