37
Participants
Start Date
January 31, 2012
Primary Completion Date
August 31, 2012
Study Completion Date
August 31, 2012
Methadone
The solution of methadone was prepared by mixing 10 ml of methadone (10 mg/ml) and 90 ml of saline 0.9% (Baxter, São Paulo, Brazil)
Ketamine
The solution of ketamine was prepared by mixing 20 ml of S(+)-ketamine hydrochloride (50 mg/ml, Cristália®, São Paulo, Brazil) and 80 ml of saline 0.9% (Baxter, São Paulo, Brazil), obtaining a concentration of 10 mg/ml of ketamine.
Methadone plus Ketamine
the solution of methadone, ketamine was prepared by mixing 10 ml of methadone hydrochloride (10 mg/ml, Cristália®, São Paulo, Brazil), 20 ml of S(+)-ketamine hydrochloride (50 mg/ml, Cristália®, São Paulo, Brazil) and 70 ml of saline 0.9% (Baxter, São Paulo, Brazil), obtaining a concentration of 1 mg/ml of methadone and 10 mg/ml of ketamine.
University Hospital in Santa Maria, Santa Maria
Santa Casa de Misericórdia de Belo Horizonte
OTHER
Hospital de Clinicas de Porto Alegre
OTHER
Universidade Federal de Santa Maria
OTHER