An Investigation Into the Cardiovascular Risk and Aetiology of CKDu in Sri Lanka

CompletedOBSERVATIONAL
Enrollment

200

Participants

Timeline

Start Date

September 30, 2014

Primary Completion Date

May 1, 2017

Study Completion Date

May 1, 2017

Conditions
CKDuArterial StiffnessProteinuriaSerum CreatinineUrinary BiomarkersDNA Adducts
Interventions
DEVICE

Arterial Stiffness Assessment

"The following will be measured: brachial systolic and diastolic bp, heart rate, mean arterial bp, pulse pressure, brachial augmentation index (difference between the amplitudes of the late (backward) systolic wave (P2) and the early (forward) systolic wave (P1) over the pulse pressure x 100), central augmentation, ejection duration of the left ventricle, return time (time of the pulse wave travelling from aortic root to the bifurcation and back), aortic pulse wave velocity ( velocity of the pulse wave in the aorta), central systolic bp, central pulse pressure and diastolic reflection area (provides information about the quality of diastolic filling in the coronary arteries).~We will perform an arterial age assessment. Patients are given a feedback form with their results to give to their general. Those with increased arterial stiffness will be tested for serum calcium and phosphate levels, and audited to ensure that a statin is commenced if not contraindicated."

Trial Locations (1)

A13

Teaching Hospital Anuradhapura, Anuradhapura

All Listed Sponsors
collaborator

Rajarata University, Sri Lanka

OTHER

lead

University of Edinburgh

OTHER

NCT02226055 - An Investigation Into the Cardiovascular Risk and Aetiology of CKDu in Sri Lanka | Biotech Hunter | Biotech Hunter