Transplantation of Partially Mismatched Related or Matched Unrelated Bone Marrow for Patients With Refractory Severe Aplastic Anemia

Day 0

0.5 mg/kg IV on Day -9 2 mg/kg IV on Days -8, -7

30 mg/M2 IV on days -6 to -2

14.5 mg/kg IV on days -6, -5, 3, 4

200 cGy on day -1

40 mg/kg IV on days 3, 4

For patients 18 years or older, tacrolimus will be given per institutional standards; may be increased or later changed to a PO BID schedule. Treatment to continue until Day 365 or longer if GVHD present

15 mg/kg PO/IV TID beginning on day 5 through day 35