Regorafenib Eye Drops: Investigation of Efficacy and Safety in Neovascular Age Related Macular Degeneration

PHASE2TerminatedINTERVENTIONAL
Enrollment

52

Participants

Timeline

Start Date

October 31, 2014

Primary Completion Date

May 31, 2015

Study Completion Date

June 30, 2015

Conditions
Macular Degeneration
Interventions
DRUG

Regorafenib, ophthalmic oily suspension (BAY73-4506)

Subjects receive Regorafenib as eye drops

PROCEDURE

Sham IVT

Sham injections

DRUG

Ranibizumab

Subjects receive Ranibizumab as intravitreal injection

DRUG

Placebo

Placebo eye drops

Trial Locations (149)

0

Bogotá

1004

Lausanne

1082

Budapest

1090

Vienna

1106

Budapest

1130

Vienna

1133

Budapest

2000

Sydney

2135

Strathfield

2145

Westmead

2150

Parramatta

3010

Bern

4032

Debrecen

6009

Nedlands

7621

Pécs

8063

Zurich

12203

Berlin

15122

West Mifflin

20122

Milan

20132

Milan

20157

Milan

20251

Hamburg

22908

Charlottesville

28803

Asheville

29605

Greenville

30030

Decatur

33076

Boredaux

33100

Udine

33143

Miami

33324

Plantation

33426

Boynton Beach

33880

Winter Haven

33912

Fort Myers

34239

Sarasota

34994

Stuart

35128

Padua

40138

Bologna

40207

Louisville

41013

Seville

41071

Seville

46014

Valencia

46015

Valencia

47012

Valladolid

47150

New Albany

48145

Münster

48903

Barakaldo

49241

Busan

49525

Grand Rapids

50134

Florence

50937

Cologne

53105

Bonn

55131

Mainz

57701

Rapid City

60126

Ancona

63031

Florissant

66211

Leawood

67226

Wichita

69003

Lyon

70535

Eunice

72076

Tübingen

75557

Paris

76508

Temple

77030

Houston

77384

The Woodlands

78240

San Antonio

78503

McAllen

78705

Austin

80401

Golden

81377

München

81675

München

85107

Bratislava

85704

Tucson

90211

Beverly Hills

91007

Arcadia

91171

Trenčín

92626

Costa Mesa

92653

Laguna Hills

92705

Santa Ana

94040

Mountain View

95008

Campbell

1834111

Afula

3109601

Haifa

3436212

Haifa

4428164

Kfar Saba

4941492

Petah Tikva

5262000

Ramat Gan

5311138

Osorno

6093000

Ẕerifin

6423906

Tel Aviv

7510168

Metropolitana

7610001

Rehovot

7650710

Vitacura

8380456

Santiago

8410101

Beersheba

9112001

Jerusalem

02114

Boston

07666

Teaneck

T2H 0C8

Calgary

T5H 0X5

Edmonton

V5Z 3N9

Vancouver

B3H 2Y9

Halifax

N6A 4V2

London

L4W 1W9

Mississauga

H1T 2M4

Montreal

H4P 2S4

Montreal

J1J 2B8

Sherbrooke

500 05

Hradec Králové

128 08

Prague

140 00

Prague

170 00

Prague

01067

Dresden

01307

Dresden

04103

Leipzig

Unknown

Hong Kong

Kowloon

00133

Rome

00198

Rome

07100

Sassari

285-0922

Inba-gun

812-0011

Fukuoka

800-0344

Miyako-gun

004-0041

Sapporo

060-8604

Sapporo

671-1227

Himeji

242-0001

Yamato

222-0011

Yokohama

860-0027

Kumamoto

518-0842

Iga

852-8511

Nagasaki

630-8305

Nara

530-0001

Osaka

533-0024

Osaka

182-0024

Chōfu

173-0015

Itabashi-ku

143-0013

Ōta-ku

111-0051

Taito-ku

03426

Ružomberok

01008

Žilina

01207

Žilina

463-707

Seongnam-si

405-760

Incheon

03080

Seoul

05505

Seoul

135-710

Seoul

137-701

Seoul

02006

Albacete

08035

Barcelona

08907

L'Hospitalet de Llobregat

08190

San Cugat Del Vallès

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Bayer

INDUSTRY