97
Participants
Start Date
December 31, 2011
Primary Completion Date
September 30, 2014
Study Completion Date
September 30, 2014
sweet block
oral application of the above mentioned substances in 300 ml tap water in 5 min. , collection of blood at 0,15,30, 60 ,120,180 minutes for measurement of incretins GIP(gastrointestinal polypeptide) and GLP-1 (glucagon like peptide 1), Protein hormones PYY(Peptide YY),CCK (cholecystokinin), Leptin and Insulin
bitter block
oral application of the above mentioned substances in 300 ml tap water, collection of blood samples at -15,0,15,30,60,120,180 min for Insulin, GIP,GLP-1, PYY and glucose
umami-block
oral application of umami substances as glutamate with and without IMP, collection of blood samples as above
gastroscopy
gastroscopy with and without oral application of saccharin, tissue samples from th upper duodenum by endoscopy for the detection of taste receptor cells in the upper bowel
Department of Clinical Nutrition, Bergholz-Rehbrücke
Technical University of Munich
OTHER
German Institute of Human Nutrition
OTHER