A Study to Investigate the Safety and Efficacy of Fidaxomicin (Oral Suspension or Tablets) and Vancomycin (Oral Liquid or Capsules) in Pediatric Subjects With Clostridium Difficile-associated Diarrhea (CDAD)

PHASE3CompletedINTERVENTIONAL
Enrollment

148

Participants

Timeline

Start Date

January 9, 2015

Primary Completion Date

March 7, 2018

Study Completion Date

March 7, 2018

Conditions
Clostridium Difficile-associated Diarrhea (CDAD)
Interventions
DRUG

Fidaxomicin oral suspension

Participants from birth to \< 6 years of age received weight based doses of fidaxomicin oral suspension (32 mg/kg/day with a maximum dose of 400 mg/day divided in 2 doses) 2 times daily for 10 days.

DRUG

Fidaxomicin tablets

Participants aged ≥ 6 years to \< 18 years of age received a 200 mg fidaxomicin tablet 2 times daily for 10 days.

DRUG

Vancomycin oral liquid

Participants from birth to \< 6 years of age received weight based doses of vancomycin oral liquid (40 mg/kg/day with a maximum dose of 500 mg/day divided in 4 doses) 4 times daily for 10 days.

DRUG

Vancomycin capsules

Participants aged ≥ 6 years to \< 18 years of age received a 125 mg vancomycin capsule 4 times daily for 10 days.

Trial Locations (44)

165

Site IT39001, Roma

1097

Site HU36006, Budapest

1200

Site BE32001, Brussels

4020

Site BE32002, Liège

6720

Site HU36004, Szeged

8950

Site ES34002, Barcelona

9000

Site BE32003, Ghent

20122

Site IT39004, Milan

27599

Site US10028, Chapel Hill

28009

Site ES34007, Madrid

28046

Site ES34004, Madrid

37604

Site US10034, Johnson City

38700

Site FR33002, La Tronche

40202

Site US10025, Louisville

43606

Site US10014, Toledo

45122

Site DE49010, Essen

46026

Site ES34003, Valencia

46202

Site US10004, Indianapolis

48149

Site DE49001, Münster

53757

Site DE49003, Saint Augustin

55131

Site DE49004, Mainz

60596

Site DE49002, Frankfurt Am M.

60637

Site US10010, Chicago

64108

Site US10032, Kansas City

67098

Site FR33008, Strasbourg

68114

Site US10030, Omaha

75012

Site FR33005, Paris

76104

Site US10038, Fort Worth

79106

Site DE49006, Freiburg im Breisgau

84113

Site US10037, Salt Lake City

92868

Site US10015, Orange

11794-8111

Site US10008, Stony Brook

45229-3039

Site US10027, Cincinnati

38105-2794

Site US10022, Memphis

L1G 2B9

Site CA15003, Oshawa

06200

Site FR33001, Nice

Site FR33007, Nice

04-730

Site PL48002, Warsaw

15 -274

Site PL48012, Bialystok

85-030

Site PL48007, Bydgoszcz

39-200

Site PL48004, Dębica

35-210

Site PL48014, Rzeszów

33-100

Site PL48006, Tarnów

Unknown

Site RO40005, Bucharest

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Astellas Pharma Europe B.V.

INDUSTRY

NCT02218372 - A Study to Investigate the Safety and Efficacy of Fidaxomicin (Oral Suspension or Tablets) and Vancomycin (Oral Liquid or Capsules) in Pediatric Subjects With Clostridium Difficile-associated Diarrhea (CDAD) | Biotech Hunter | Biotech Hunter