Post-operative Adjuvant Treatment for HPV-positive Tumours (PATHOS)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

1,269

Participants

Timeline

Start Date

October 31, 2015

Primary Completion Date

October 31, 2027

Study Completion Date

April 30, 2028

Conditions
Human Papillomavirus (HPV)-Positive Oropharyngeal Cancer
Interventions
DRUG

Cisplatin

Chemotherapy

RADIATION

Postoperative radiotherapy

Postoperative radiotherapy (PORT)

Trial Locations (57)

32803

Advent Health, Orlando

42653

Städtisches Klinikum Solingen, Solingen

75013

Unicancer, Paris

77030

MD Anderson Cancer Centre, Houston

94063

Board of Trustees of the Leland Stanford Junior University, Redwood City

QLD 4113

Metro South Health, Brisbane

Unknown

Vivantes Klinikum, Berlin

Zentrum für Hals-, Nasen- und Ohrenheilkunde, Giessen

Asklepios Kliniken, Hamburg

Kath Marienkrankenhaus gGmbH, Hamburg

Universitaetsklinikum des Saarlandes, Homburg

Universitat Leipzig, Leipzig

Ernst von Bergmann Klinikum, Potsdam

Universitätsklinikum Ulm, Ulm

Kent and Canterbury Hospital, Canterbury

Royal Devon University Health Care NHS Foundation Trust, Exeter

Northampton General Hospital, Northampton

Nottingham City Hospital, Nottingham

Royal Stoke Hospital, Stoke

BH15 2JB

University Hospitals Dorset NHS Foundation, Poole

BA1 3NH

Royal United Hospitals Bath NHS Foundation Trust, Bath

B15 2TH

Queen Elizabeth Hospital, Birmingham

BB2 3HH

Royal Blackburn Hospital, Blackburn

BN2 5BE

Royal Sussex County Hospital, Brighton

BS2 8ED

University Hospitals Bristol NHS Foundation Trust, Bristol

CB2 0QQ

Cambridge University Hospitals NHS Foundation Trust, Cambridge

CF14 4XN

HPV Research Group Section of Pathology Cardiff University ,School of Medicine, Cardiff

CF14 4XW

Cardiff and Vale University Local Health Board, Cardiff

CF14 4YS

Centre for Trials Research, Cardiff

CF142TL

Velindre NHS Trust, Cardiff

HU16 5JQ

Castle Hill Hospital, Cottingham

DE22 3DT

Derby Teaching Hospitals NHS Foundation Trust, Derby

EH4 2XU

Western General Hospital, Edinburgh

GU2 7XX

Royal Surrey County Hospital, Guildford

LS9 7TF

St James University Hospital, Leeds

L3 9TA

Liverpool Head and Neck Centre, Liverpool

L69 3GB

University of Liverpool, Liverpool

CF72 8XR

Cwm Taf Bro Morganwg, Llantrisant

NW1 2BU

University College London Hospitals NHS Foundation Trust, London

SE1 9RT

Guys and St Thomas's NHS Foundation Trust, London

SW17 0QT

St Georges University Hospital, London

SW7 2AZ

Imperial College Healthcare NHS Trust, London

M13 9WL

Central Manchester University Hospital NHS Foundation Trust, Manchester

M20 4BX

The Christie NHS Foundation Trust, Manchester

OL1 2JH

The Pennine Acute Hospital Trust, Manchester

TS4 3BW

The James Cook University Hospital, Middlesbrough

NE1 4LP

Royal Victoria Infirmary, Newcastle upon Tyne

NE7 7DN

Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne

NP18 3XQ

Aneurin Bevan University Health Board, Newport

OX3 7LD

Oxford University Hospitals NHS Foundation Trust, Oxford

PL6 8DH

University Hospital Plymouth, Plymouth

PO6 3LY

Queen Alexandra Hospital, Portsmouth

PR2 9HT

Royal Preston Hospital, Preston

RG1 5AN

Royal Berkshire Hospital, Reading

SO16 6YD

University Hospital Southampton, Southampton

SR4 7TP

City Hospitals Sunderland NHS Foundation Trust, Sunderland

SA2 8QA

Swansea Bay University Local Health Board, Swansea

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

UNICANCER

OTHER

collaborator

AdventHealth

OTHER

collaborator

University of Leipzig

OTHER

collaborator

Princess Alexandra Hospital, Brisbane, Australia

OTHER

collaborator

Stanford University

OTHER

lead

Lisette Nixon

OTHER_GOV