660
Participants
Start Date
September 1, 2014
Primary Completion Date
January 16, 2017
Study Completion Date
May 1, 2017
Genotype-guided dosing algorithm for warfarin
Intervention：initial dosing of warfarin for the first 3 days of treatment will be determined by IWPC( International Warfarin Pharmacogenetics Consortium) algorithm (PG-1),a second dose adjustment will be made after 3 doses of warfarin using a dose revision algorithm (PG-2) that combined INR values,the dose will be adjusted depending on the measurements of INR values after 7 days.The overall follow-up period is 12 weeks.
Standard initiation dose for warfarin
Intervention：initial dosing of warfarin for the first 3 days of treatment will be determined by standard initiation dose. Following this initiation dose of warfarin,the dose will be adjusted depending on the measurements of INR values after 3 days.The overall follow-up period is 12 weeks.
The People's Hospital of Hunan Province, Changsha
The Central Hospital of Changsha, Changsha
The Fourth Hospital of Changsha, Changsha
The Third Xiangya Hospital of Central South University, Changsha
The Central Hospital of Xiangtan, Xiangtan
The First People's Hospital of Xiangtan, Xiangtan
The Central Hospital of Yiyang, Yiyang
The Central Hospital of Loudi, Loudi
The Central Hospital of Shaoyang, Shaoyang
The First People's Hospital of Shaoyang, Shaoyang
The First People's Hospital of Chenzhou, Chenzhou
The Third Hospital of Changsha, Changsha
The Xiangya Hospital of Central South University, Changsha
The First Affiliated Hospital of Nanhua university, Hengyang
The Second Affiliated Hospital of Nanhua university, Hengyang
The Third Xiangya Hospital of Central South University
OTHER