Phosphate Lowering in CKD Trial

Non-calcium containing phosphorus binder

Table identical to lanthanum carbonate but with no active ingredient

Intravenous administration during measurement of flow mediated dilation.

Drug that is administered under the tongue that relaxes blood vessels. To be administered during measurement of flow mediated dilation.

Measurement of the blood flow in the brachial artery, an artery in the upper arm, using ultrasound.

Measurement of the stiffness of the arteries using a transcutaneous tonometer, a small device placed over the skin over the carotid, brachial, radial and femoral arteries.

Collection of endothelial cells from vein in arm. A flexible wire is inserted through an IV into a forearm vein to collect endothelial cells for further study. This is performed at the baseline visit and and the final study visit.