Simultaneous TransPRK and Corneal Collagen Cross-Linking

NACompletedINTERVENTIONAL
Enrollment

55

Participants

Timeline

Start Date

August 31, 2014

Primary Completion Date

July 31, 2016

Study Completion Date

July 31, 2017

Conditions
Keratoconus
Interventions
PROCEDURE

Transepithelial Photorefractive Keratectomy (TransPRK)

Aberrometry or topography guided transepithelial photorefractive keratectomy (TransPRK) using the Schwind Amaris 750s excimer laser (www.eye-tech-solutions.com), an 8mm treatment diameter, and a tissue saving algorithm targeting selected higher order aberrations only. TransPRK will be followed immediately by corneal collagen cross-linking (CXL).

PROCEDURE

Corneal Collagen Cross-Linking (CXL)

"Riboflavin soak: 10 minutes total soak time; application of 0.1% riboflavin preparation (VibeX Rapid - www.avedro.com) each 2 minutes with gentle balanced salt solution irrigation to remove excess riboflavin prior to UV light exposure.~UV light exposure: Total treatment time 8 minutes (370nm wavelength; 30mW/cm2 irradiance; 4 minutes total UV exposure time, pulsed 1.5 seconds on 1.5 seconds off; Avedro KXL I light source)"

Trial Locations (1)

EC1V 2PD

Moorfields Eye Hospital NHS Foundation Trust, 162 City Road, London

All Listed Sponsors
collaborator

Moorfields Eye Hospital NHS Foundation Trust

OTHER

lead

Bruce Allan

OTHER

NCT02208089 - Simultaneous TransPRK and Corneal Collagen Cross-Linking | Biotech Hunter | Biotech Hunter