1,400
Participants
Start Date
November 2, 2016
Primary Completion Date
July 31, 2026
Study Completion Date
July 31, 2026
Prednisone
Stratum I
Vinblastine
Stratum I
mercaptopurine
Stratum I
INDOMETHACIN
Indomethacin fixed dose given daily orally in two divided doses with gastric protection for total treatment duration of 24 months.
Methotrexate
fixed dose weekly orally for total treatment duration of 24 months.
Cytosine Arabinoside
2-chlorodeoxyadenosine
hematopoietic stem cell transplantation (RIC-HSCT)
Intravenous immunoglobulin
RECRUITING
Mount Sinai Hospital, New York
RECRUITING
Columbia University / Herbert Irving Cancer Center, New York
RECRUITING
Memorial Sloan Kettering Cancer Center, New York
RECRUITING
Children's Hospital at Montefiore, The Bronx
RECRUITING
Cohen Children's Medical Center, New Hyde Park
RECRUITING
SUNY Upstate Medical University, Syracuse
RECRUITING
UPMC Children's Hospital of Pittsburgh, Pittsburgh
RECRUITING
Children's National Medical Center, Washington D.C.
RECRUITING
Johns Hopkins University, Baltimore
RECRUITING
Carolinas Medical Center, Levine Children's Hospital, Charlotte
RECRUITING
Medical University of South Carolina (MUSC), Charleston
RECRUITING
Greenville Health System BI-LO Charities Children's Cancer Center, Greenville
RECRUITING
Children's Healthcare of Atlanta, Emory, Atlanta
RECRUITING
Johns Hopkins All Children's Hospital, St. Petersburg
RECRUITING
Children's of Alabama, Birmingham
NOT_YET_RECRUITING
Vanderbilt-Ingram Cancer Center, Nashville
RECRUITING
St. Jude Children's Research Hospital, Memphis
RECRUITING
University of Louisville, Norton Children's Hospital, Louisville
COMPLETED
University of Kentucky A.B.Chandler Medical Center, Lexington
RECRUITING
Russell J Ebeid Children's Hospital (Promedica), Toledo
RECRUITING
Rainbow Babies & Children's Hospital, University Hospitals, Cleveland
RECRUITING
Akron Children's Hospital, Akron
COMPLETED
Cincinnati Children's Hospital Medical Center, Cincinnati
NOT_YET_RECRUITING
Riley Hospital for Children - Indiana University, Indianapolis
RECRUITING
American Family Children's Hospital University of Wisconsin, Madison
NOT_YET_RECRUITING
Children's Minnesota, Minneapolis
RECRUITING
Children's Mercy Hospitals, Kansas City
RECRUITING
Arkansas Children's Hospital, Little Rock
RECRUITING
Children's Medical Center Dallas, UT Southwestern, Dallas
RECRUITING
Phoenix Children's Hospital, Phoenix
NOT_YET_RECRUITING
Children's Hospital of Los Angeles, Los Angeles
RECRUITING
Children's Hospital of Orange County, Orange
RECRUITING
Valley Children's Healthcare, Madera
COMPLETED
UCSF Benioff Children's Hospital of Oakland, Oakland
RECRUITING
Madigan Army Medical Center, Tacoma
RECRUITING
Providence Sacred Heart Children's Hospital, Spokane
RECRUITING
UCSF Helen Diller Family Cancer Center, San Francisco
RECRUITING
Connecticut Children's Medical Center, Hartford
RECRUITING
Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago
RECRUITING
Massachusetts General Hospital, Boston
RECRUITING
Dana Farber Cancer Institute, Boston
RECRUITING
Hackensack University Medical Center, Hackensack
Histiocyte Society
OTHER
North American Consortium for Histiocytosis
OTHER