A Study to Assess the Safety and Efficacy of the VEGFR-FGFR-PDGFR Inhibitor, Lucitanib, Given to Patients With Metastatic Breast Cancer

PHASE2TerminatedINTERVENTIONAL
Enrollment

178

Participants

Timeline

Start Date

September 9, 2014

Primary Completion Date

January 17, 2017

Study Completion Date

January 18, 2017

Conditions
Breast CancerMetastatic Breast CancerMBCHER2 PositiveHER2Estrogen Receptor PositiveERTriple Negative
Interventions
DRUG

Lucitanib

Lucitanib is a potent, orally available selective inhibitor of the tyrosine kinase activity of fibroblast growth factor receptors (FGFR1-3), vascular endothelial growth factor receptors (VEGFR1-3), and platelet-derived growth factor receptors alpha and beta (PDGFR alpha and beta)

Trial Locations (33)

10065

Memorial Sloan-Kettering Cancer Center, New York

Weill Cornell Breast Center, New York

10469

Sciode Medical Associates, PLLC, The Bronx

15213

University of Pittsburgh Medical Center, Pittsburgh

21231

The Sidney Kimmel Comprehensive Cancer Center at John Hopkins, Baltimore

23502

Virginia Oncology Associates, Norfolk

33021

Memorial West Cancer Center, Hollywood

33442

University of Miami, Deerfield Beach

37203

Sarah Cannon Cancer Center, Nashville

37232

Vanderbilt Ingram Cancer Center, Nashville

44106

University Hospitals Case Medical Center, Cleveland

46202

Indiana University Simon Cancer Center, Indianapolis

47905

Horizon Oncology Center, Lafayette

60611

Northwestern University, Robert H. Lurie Comprehensive Cancer Center, Chicago

60637

University of Chicago Medical Center, Chicago

75246

Texas Oncology - Baylor Charles A. Sammons Cancer Center, Dallas

76104

The Center for Cancer and Blood Disorders, Fort Worth

77024

US Oncology, Houston

78731

Texas Oncology - Austin Central, Austin

86336

Arizona Oncology Associates, Sedona

89169

Comprehensive Cancer Centers of Nevada, Las Vegas

90033

University of Southern California, Los Angeles

90048

Cedars-Sinai Medical Center, Los Angeles

90095

University of California, Los Angeles, Los Angeles

90277

Cancer Care Associates Medical Group, Inc., Redondo Beach

92093

Moores UCSD Cancer Center, La Jolla

92835

Saint Jude Heritage Medical Center, Fullerton

93309

Comprehensive Blood and Cancer Center, Bakersfield

93454

Central Coast Medical Oncology Group, Santa Maria

94115

University of California San Francisco, San Francisco

06519

Yale University, New Haven

02115

Dana Farber Cancer Institute, Boston

08043

Cooper University Hospital, Voorhees Township

Sponsors
All Listed Sponsors
lead

Clovis Oncology, Inc.

INDUSTRY

NCT02202746 - A Study to Assess the Safety and Efficacy of the VEGFR-FGFR-PDGFR Inhibitor, Lucitanib, Given to Patients With Metastatic Breast Cancer | Biotech Hunter | Biotech Hunter