60
Participants
Start Date
February 11, 2015
Primary Completion Date
July 16, 2020
Study Completion Date
July 16, 2020
Bortezomib
"1. Five plasma exchanges +0.1 g/kg of intravenous immunoglobulins at the end of each course~2. two cycles of bortezomib (1.3 mg/m2 IV at day-1, day-4, day-8, day-11) + oral dexamethasone (20 mg po at day-1, day-4, day-8, day-11)~3. four courses of polyclonal intravenous immunoglobulins every three weeks (2g/kg, the first two courses are performed simultaneously with the two bortezomib cycles)"
Plasma exchanges and intravenous immunoglobulins
"1. Five plasma exchanges +0.1 g/kg of intravenous immunoglobulins at the end of each course~2. four courses of polyclonal intravenous immunoglobulins every three weeks (2g/kg)~3. oral dexamethasone (20 mg po at day-1, day-3, day-5, day-7 of the two first intravenous immunoglobulins courses)"
Hopital Necker Enfants-malades, Paris
Fondation Centaure
OTHER
Assistance Publique - Hôpitaux de Paris
OTHER