Efficacy and Safety Study of BOTOX® Compared to Topiramate for the Prevention of Chronic Migraine in Adults

PHASE4CompletedINTERVENTIONAL
Enrollment

282

Participants

Timeline

Start Date

August 5, 2014

Primary Completion Date

May 9, 2017

Study Completion Date

September 1, 2017

Conditions
Migraine Disorders
Interventions
BIOLOGICAL

onabotulinumtoxinA

155U onabotulinumtoxinA (BOTOX®) total dose per treatment by intramuscular injection every 12 weeks.

DRUG

Topiramate

Topiramate up to a maximum oral dose of 100 mg/day.

Trial Locations (32)

10461

Montefiore Headache Center, The Bronx

11803

Island Neurological Associates PC, Plainview

14226

Dent Neurosciences Research Center Incorporated, Amherst

15236

Preferred Primary Care Physicians, Pittsburgh

19096

Main Line Health Lankenau Hospital, Wynnewood

19107

Thomas Jefferson University, Philadelphia

27405

Headache Wellness Center, Greensboro

27607

Raleigh Neurology Associates PA, Raleigh

28806

Asheville Neurology Specialists PA, Asheville

32561

NW FL Clinical Research Group, LLC, Gulf Breeze

33172

Design Neuroscience Center, Doral

33407

Neurology Research Institute at Palm Beach Neurology, West Palm Beach

33486

Parkinson's Disease and Movement Disorders Center of Boca Raton Inc, Boca Raton

34239

Negroski, Sutherland & Hanes Neurology, Sarasota

49201

Allegiance Health, Jackson

60015

Robbins Headache Clinic, Riverwoods

63141

Mercy Health Research, St Louis

65807

Clinvest, Springfield

66210

International Clinical Research Institute Inc, Overland Park

66211

Kansas City Bone and Joint Clinic, Overland Park

70810

The NeuroMedical Center, Baton Rouge

75214

Texas Neurology, Dallas

80210

Denver Neurological Clinic, Denver

85013

St Joseph's Hospital Barrow Neurology Clinics, Phoenix

89502

Renown Institute for Neurosciences, Reno

92024

North County Neurology Associates, Encinitas

92663

Newport Beach Clinical Research Associates, Inc., Newport Beach

93723

California Headache and Balance Center, Fresno

98409

Puget Sound Neurology, Tacoma

06905

Ki Health Partners LLC DBA New England Institute for Neurology and Headache, Stamford

02472

MedVadis Research Corporation, Watertown

01605

New England Regional Headache Center Inc, Worcester

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Allergan

INDUSTRY