30
Participants
Start Date
January 31, 2015
Primary Completion Date
September 30, 2016
Study Completion Date
September 30, 2016
[F18]-T807
\[F18\]-T807 PET Scan to measure tau deposition in the brain.
[F18]-Florbetapir
\[F18\]-Florbetapir PET scan to measure Beta-amyloid deposition in the brain.
MRI/MRS
Two scans (structural, diffusion tensor imaging, and susceptibility weighted imaging scanned as part of one MR protocol, and a one-dimensional and two-dimensional spectroscopy examination as part of the other MR protocol.
Genetic Analysis for Genetic Risk Score for Tau.
DNA will be extracted from previously acquired and de-identified frozen blood specimens using a standard protocol (Gentra Puregene Kit, Qiagen 158422). Genotyping will be performed using the iPLEX Sequenom MassARRAY platform and samples will be genotyped for single nucleotide polymorphisms (SNPs) associated with the deposition of neurofibrillary tangles.
Boston University Medical Center, Boston
Brigham and Women's Hospital, Boston
U.S. Army Medical Research and Development Command
FED
Boston University
OTHER
Brigham and Women's Hospital
OTHER