1,310
Participants
Start Date
July 28, 2014
Primary Completion Date
May 9, 2022
Study Completion Date
September 7, 2022
Tranexamic Acid
Tranexamic acid is a synthetic lysine derivative that inhibits fibrinolysis by blocking the lysine binding sites on plasminogen therefore inhibiting the conversion of plasminogen to plasmin. Intravenous injection of 1g Tranexamic Acid will be administered in the pre-hospital setting followed by 1g Tranexamic Acid infused intravenously over 8 hours initiated in the hospital emergency department.
Placebo
Auckland City Hospital, Auckland
Ambulance Victoria, Melbourne
Middlemore Hospital, Auckland
Ambulance Service of New South Wales, Rozelle
Royal North Shore Hospital, St Leonards
Westmead Hospital, Westmead
CareFlight, Northmead
Liverpool Hospital, Sydney
John Hunter Hospital, Newcastle
Lismore Base Hospital, Lismore
NNSW Medical Retrieval Service, Lismore
Wagga Wagga Base Hospital, Wagga Wagga
Orange Base Hospital, Orange
The Alfred Hospital, Melbourne
Royal Melbourne Hospital, Melbourne
Waikato Hospital, Hamilton West
Royal Brisbane and Women's Hospital, Brisbane
Queensland Ambulance Service, Kedron
Princess Alexandra Hospital, Brisbane
Hawke's Bay, Hastings
Gold Coast Hospital, Gold Coast
Royal Adelaide Hospital, Adelaide
Flinders Medical Centre, Bedford Park
South Australia Ambulance Service, Eastwood
Royal Perth Hospital, Perth
Wellington Free Ambulance, Wellington
Wellington Hospital, Wellington
St John Ambulance Western Australia, Geraldton
Ambulance Tasmania, Hobart
Royal Hobart Hospital, Hobart
St John Ambulance, Darwin
Royal Darwin Hospital, Darwin
St John Ambulance, Albany
National Health and Medical Research Council, Australia
OTHER
Health Research Council, New Zealand
OTHER
Monash University
OTHER