Antibiotherapy During Therapeutic Hypothermia to Prevent Infectious Complications

PHASE3CompletedINTERVENTIONAL
Enrollment

197

Participants

Timeline

Start Date

August 18, 2014

Primary Completion Date

October 27, 2016

Study Completion Date

September 14, 2017

Conditions
Ventilator-associated PneumoniaCardiac Arrests With Shockable RhythmMild Therapeutic HypothermiaPreventive Antibiotics
Interventions
DRUG

Amoxicillin - clavulanic acid

Amoxicillin-clavulanic acid 1g, three times a day during 2 days, started within one hour after randomization and before the beginning of hypothermia.

DRUG

Placebo

Placebo 1g, three times a day during 2 days, started within one hour after randomization and before the beginning of hypothermia.

Trial Locations (16)

16470

CH Angouleme - Service de Réanimation, Angoulême

19100

CH Brive La Gaillarde - Service de Réanimation, Brive-la-Gaillarde

21079

CHU Dijon - Serve de Réanimation, Dijon

24019

CH Périgueux, Périgueux

37044

CHU Tours - Service de Réanimation, Tours

47067

CHU Orléans - service de Réanimation, Orléans

67000

CHU Strasbourg - service de Réanimation, Strasbourg

72000

CH du MANS, Le Mans

75010

AP-HP - Hôpital Lariboisière - Service de Réanimation, Paris

75014

AP-HP - Hôpital Cochin - Service de Réanimation, Paris

75015

AP-HP - Hôpital Européen Georges Pompidou - Service de Réanimation, Paris

78000

CH Versailles - service de Réanimation, Versailles

87042

CHU de Limoges - Service de réanimation polyvalente, Limoges

92380

AP-HP - Hôpital pointcaré - Service de Réanimation, Garches

95107

CH Argenteuil - Service de Réanimation, Argenteuil

Unknown

CHU Nantes - Service de réanimation, Nantes

All Listed Sponsors
lead

University Hospital, Limoges

OTHER

NCT02186951 - Antibiotherapy During Therapeutic Hypothermia to Prevent Infectious Complications | Biotech Hunter | Biotech Hunter