Ceritinib (LDK378) for Patients Whose Tumors Have Aberrations in ALK or ROS1 (SIGNATURE)

PHASE2TerminatedINTERVENTIONAL
Enrollment

47

Participants

Timeline

Start Date

September 17, 2014

Primary Completion Date

December 13, 2017

Study Completion Date

December 13, 2017

Conditions
Tumors With Aberrations in ALK or ROS1
Interventions
DRUG

Ceritinib

Ceritinib was dosed on a flat scale of 750 mg (e.g., 5 x 150 mg capsules) orally,once daily, on a continuous dosing cycle. A complete treatment cycle was defined as 28 days. There were no breaks between dosing cycles.

Trial Locations (21)

17011

Andrew and Patel Associates, Camp Hill

20910

Holy Cross Hospital Holy Cross (2), Silver Spring

27157

Wake Forest Baptist Health Health Sciences, Winston-Salem

27710

Duke University Medical Center Seeley G. Mudd Bldg., Durham

33901

Florida Cancer Specialists Florida Cancer Specialists (31, Fort Myers

39705

Columbus Hematology and Oncology PA Columbus Hem and Onc (2), Columbus

52403

Physicians Clinic of Iowa, Cedar Rapids

53226

Aurora Research Institute, Milwaukee

57104

Sanford University of South Dakota Medical Center Sanford Clinical Research, Sioux Falls

58122

Sanford Hematology Oncology, Fargo

60611

Northwestern University Northwestern (6), Chicago

68510

Southeast Nebraska Oncology, Lincoln

77024

Oncology Consultants Oncology Group, Houston

77030

MD Anderson Cancer Center/University of Texas MD Anderson Cancer Center (3), Houston

80218

Sarah Cannon Research Institute, Denver

84106

Utah Cancer Specialists Utah Cancer Specialists, Salt Lake City

89109

Comprehensive Cancer Centers of Nevada CCC of Nevada (1), Las Vegas

94503

St Joseph Heritage Healthcare St. Joseph Heritage, Santa Rosa

98104

Swedish Cancer Institute Swedish Cancer Institute, Seattle

Unknown

Rocky Mountain Cancer Centers Dept of Rocky Mountain (2), Greenwood Village

02903

Rhode Island Hospital Rhode Island Hosp. (2), Providence

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY