Targeted Chemotherapy Using Focused Ultrasound for Liver Tumours

PHASE1CompletedINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

July 31, 2014

Primary Completion Date

March 31, 2017

Study Completion Date

April 30, 2017

Conditions
Liver Tumour
Interventions
DRUG

ThermoDox® (LTLD)

ThermoDox® (LTLD) infusion at a dose of 50mg/m2 whilst under general anaesthetic during intervention (Day 1)

DEVICE

Focused Ultrasound of Target Liver Tumour

Whilst the ThermoDox® was circulating in the blood stream, the JC200 Therapeutic Ultrasound device was used to induce mild hyperthermia in a single (region of) a target liver tumour.

DIAGNOSTIC_TEST

Pre-LTLD Biopsy of Target Liver Tumour

DIAGNOSTIC_TEST

Post-LTLD Biopsy of Target Liver Tumour

DIAGNOSTIC_TEST

Post-LTLD+FUS (Post-FUS) Biopsy of Target Liver Tumour

DEVICE

Thermometry of Target Tumour

A clinically approved thermistor or thermocouple was placed in the target liver tumour for real-time thermometry.

Trial Locations (1)

OX3 7LE

Oxford University Hospitals NHS Trust, Oxford

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Oxford University Hospitals NHS Trust

OTHER

collaborator

Imunon

INDUSTRY

lead

University of Oxford

OTHER

NCT02181075 - Targeted Chemotherapy Using Focused Ultrasound for Liver Tumours | Biotech Hunter | Biotech Hunter