A Randomised Controlled Trial of Remifentanil Intravenous Patient Controlled Analgesia (PCA) Versus Intramuscular Pethidine for Pain Relief in Labour

PHASE4CompletedINTERVENTIONAL
Enrollment

401

Participants

Timeline

Start Date

May 31, 2014

Primary Completion Date

September 30, 2016

Study Completion Date

September 30, 2016

Conditions
Pain Relief in Labour
Interventions
DRUG

Pethidine

100mg by intramuscular injection, up to 4 hourly in frequency (up to a maximum of 4 doses). The maximum dose being 400mg in 24 hours.

DRUG

Remifentanil

"Dedicated intravenous cannula for remifentanil administration PCA protocol~* PCA bolus remifentanil 40 μg~* Lockout interval 2 minutes~In the event of excess sedation being recorded by regular observation of respiratory function, the regimen will be altered by reduction of the remifentanil bolus dose to 30 μg with a lock-out interval of 2 minutes."

Trial Locations (1)

B15 2TT

Birmingham Clinical Trials Unit, Birmingham

All Listed Sponsors
collaborator

Heartlands Hospital

UNKNOWN

collaborator

Good Hope Hospital

UNKNOWN

collaborator

Birmingham Women's NHS Foundation Trust

OTHER_GOV

collaborator

York Hospital

UNKNOWN

collaborator

University Hospital of North Midlands

UNKNOWN

collaborator

Frimley Park Hospital

UNKNOWN

collaborator

Bradford Royal Infirmary

OTHER

collaborator

Stoke Mandeville Hospital

UNKNOWN

collaborator

Clinical Research and Trials Unit (Norfolk & Norwich University Hospital, UK)

OTHER

collaborator

Medway Maritime Hospital

UNKNOWN

collaborator

Northwick Park Hospital

OTHER

collaborator

Homerton University Hospital

UNKNOWN

collaborator

City Hospital Birmingham

UNKNOWN

collaborator

Warwick Hospital

UNKNOWN

collaborator

University Hospital Coventry

UNKNOWN

lead

University of Birmingham

OTHER

NCT02179294 - A Randomised Controlled Trial of Remifentanil Intravenous Patient Controlled Analgesia (PCA) Versus Intramuscular Pethidine for Pain Relief in Labour | Biotech Hunter | Biotech Hunter