714
Participants
Start Date
October 31, 2014
Primary Completion Date
September 20, 2017
Study Completion Date
September 20, 2017
BBI608
BBI608 480 mg orally two times daily (960 mg total daily dose)
Paclitaxel
Paclitaxel 80 mg/m2 I.V. infusion on Days 1, 8, and 15 of every 4-week cycle
Placebo
Orally two times daily
Institut Jules Bordet, Brussels
Semmelweis Egyetem, Budapest
UZ Brussel - Campus Jette, Brussels
Egyesített Szent István és Szent László Kórház-Rendelőintéze, Budapest
Országos Onkológiai Intézet, Budapest
Semmelweis Egyetem, Budapest
District Dispensery with Stationary - Sofia District, Sofia
Multiprofile hospital for active treatment, Sofia
Universitätsklinik Carl-Gustav-Carus Dresden, Dresden
"UMHATSv.Ivan Rilski", Sofia
Specialised Hospital for Active Treatment in Oncology, Sofia
St Vincent's Hospital, Darlinghurst
Chris O'Brien Lifehouse, Camperdown
Royal North Shore Hospital, St Leonards
Bankstown-Lidcombe, Bankstown
Central coast area health (public), Gosford
Port Macquaries Base Hospital, Port Macquarie
Riverina Cancer Care Centre, Wagga Wagga
UZ Antwerpen, Edegem
Imelda Ziekenhuis, Bonheiden
UZ Leuven - Campus Gasthuisberg, Leuven
COC - Vratsa Dept. of Palliative Care, Vratsa
Sunshine Hospital, St Albans
Royal Melbourne Hospital, Parkville
St Vincent's Hospital, Fitzroy
Austin Hospital, Heidelberg
Ballarat base hospital, Heidelberg
Monash Health, East Bentleigh
Peninsula & South Eastern Haematology and Oncology Group, East Bentleigh
Ballarat Oncology and Haematology Services, Wendouree
Bendigo Hospital, Bendigo
CHU de Liège - Domaine Universitaire du Sart Tilman, Liège
Royal Brisbane & Women's Hospital, Herston
Princess Alexandra Hospital, Woolloongabba
Universitätsklinikum Leipzig, Leipzig
Gold Coast University Hospital, Southport
Josa Andras Oktato Korhaza, Nyíregyháza
Sunshine Coast Hospital and Health Service, Nambour
Townsville Hospital, Townsville
Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház- Rendelőinté, Szolnok
The Queen Elizabeth Hospital, Woodville
Ashford Cancer Centre Research, Kurralta Park
Flinders Medical Centre, Bedford Park
Békés Megyei Pándy Kálmán Kórház, Gyula
"UMHAT Dr. Georgi Stranski Dept. Medical Oncology", Pleven
Fiona Stanley Hospital, Subiaco
CHU Ambroise Paré, Mons
Somogy Megyei Kaposi Mór Oktató Kórház, Kaposvár
Pécsi Tudományegyetem Klinikai Központ, Pécs
AZ Sint-Lucas - Campus Sint-Lucas, Brugge (Assebroek)
Uni. Multiprofile Hospital for Active treatment Sveta Marina, Varna
Petz Aladár Megyei Oktató Kórház, Győr
Weill Medical College of Cornell University, New York
Ospedale Molinette, AO Città della Salute e della Scienza di, Torino
East Tallinn Central Hospital Oncology Center, Tallinn
Charite - Campus Benjamin Franklin (Cbf), Berlin
Hopital Saint Joseph - Marseille, Marseille
State University of New York Upstate Medical University, Syracuse
Charite, Berlin
CHU - Hôpital De La Timone, Marseille
AOU S.Martino, IRCCS, IST-Istituto Nazionale Ricerca Sul Can, Genova
Geisinger Medical Center, Danville
Azienda Ospedaliera Fatebenefratelli e Oftalmico, Milan
Facharztzentrum Eppendorf, Hamburg
OncoResearch Lerchenfeld GmbH, Hamburg
Humanitas Gavazzeni, Bergamo
"Azienda Ospedaliera Istituti Ospitalieri di Cremona", Cremona
Indiana University Health University Hospital, Chapel Hill
H.G.U. G. Marañón, Madrid
M.D. Anderson Cancer Center Madrid, Madrid
H.U. R. y Cajal, Madrid
H.C. S.Carlos, Madrid
H.U.P Hierro-Majadahonda, Majadahonda
Ospedale Guglielmo da Saliceto, AUSL Piacenza, Piacenza
Hôpital Morvan - CHRU de Brest, Brest
H.U.V.Arrixaca, Murcia
Centre Hospitalier Universitaire (CHU) de Toulouse - Hopital, Toulouse
Rambam Health Care Campus, Haifa
Ev. Krankenhaus Bielefeld, Bielefeld
Centre eugène marquis, Rennes
Istituto Oncologico Veneto IOV-IRCCS, Padua
Centre Hospitalier De Mont De Marsan - Hopital Layné, Mont-de-Marsan
Policlinico S.Orsola Malpighi, AOU di Bologna, Bologna
H.U.V. Macarena, Seville
H.U.V. del Rocío, Seville
CHU Saint Etienne, Saint-Etienne
Ohio State University Medical Center, Columbus
Meir Medical Center, Kfar Saba
Centre Paul Papin, Saint-Herblain
Centre Rene Gauducheau, Saint-Herblain
Kliniken Essen-Mitte Evang. Huyssens-Stiftung, Essen
C.H.G.U.de Valencia, Valencia
Indiana University Health Goshen Center For Cancer Care, Goshen
Northern Indiana Cancer Research Consortium, South Bend
Irccs Irst, Meldola
AUSL della Romagna, Osp. degli Infermi, Faenza
Unità di Biostatistica e Sperimentazioni Cliniche IRST, Ravenna
Rabin Medical Center - Beilinson Hospital, Petah Tikva
Spectrum Health Butterworth, Grand Rapids
Munson Medical Center, Traverse City
H.U. Miguel Servet, Zaragoza
Tartu University Hospital Clinic of Hematology and Oncology, Tartu
Siouxland Regional Cancer Center, Sioux City
Saint Vincent Hospital CCOP, Green Bay
St. Mary's Hospital, Green Bay
Marshfield CCOP, Marshfield
Gundersen Lutheran Medical Center, La Crosse
Johannes Gutenberg-Universitaet, Maintz
Metro-Minnesota NCI CORP, Saint Louis Park
Mayo Clinic - Rochester, Rochester
The E. Wolfson Medical Center [Oncology], Holon
Ospedale Umberto I, AOU Ospedali Riuniti Umberto I - GM.Lanc, Ancona
Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main
CHU Estaing, Clermont-Ferrand
Heartland NCORP, St Louis
Tel Aviv Sourasky Medical Center, Tel Aviv
Cancer Center of Kansas, Wichita
Hopital Privé Jean Mermoz, Lyon
Ochsner NCI CORP, New Orleans
The University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City
Klinikum Esslingen, Esslingen am Neckar
Colorado Cancer Research Program, Denver
Klinikum Bogenhausen, München
Soroka Medical Center [Oncology], Beersheba
Mayo Clinic - Arizona, Scottsdale
Chd Vendee La Roche Sur Yon, La Roche-sur-Yon
Hospital of Poitiers, Poitiers
Hadassah Medical Organisation, Jerusalem
Institut Gustave Roussy, Villejuif
PO Garibaldi-Nesima, ARNAS Garibaldi, Catania
Virginia Mason Medical Center, Seattle
Swedish Cancer Institute/ Swedish Health Services, Seattle
Cancer Hospital Chinese Academy of Medical Sciences, Beijing
The 307th Hospital of Chinese People's Liberation Army, Beijing
Beijing Cancer Hospital, Beijing
Chinese PLA General Hospital, Beijing
The First Hospital of China Medical University, Shenyang
Russian Oncological Research Center n.a. N.N. Blokhin RAMS, Moscow
City Clinical Hospital #40, Moscow
The First Bethune Hospital of Jilin University, Changchun
Jilin Cancer Hospital, Jilin
Harbin Medical University Cancer Hospital, Heilongjiang
Military Medical Academy n.a. S.M. Kirov, Saint Petersburg
Northwestern State Medical University n.a. Mechnikov, Saint Petersburg
First Pavlov State Medical University of Saint-Petersburg, Saint Petersburg
GBUZ Saint Petersburg clinical scientific and practical cent, Saint Petersburg
SPb State Budget Institution Oncology Dispansery, Saint Petersburg
Fudan University Shanghai Cancer Center, Shanghai
Zhongshan Hospital, Shanghai
Centrul de Oncologie Sf. Nectarie, Craiova
Oncolab, Craiova
The 81 Hospital of the Chinese People's Liberation Army, Nanjing
Jiang Su Cancer Hospital, Nanjing
Jiangsu Province Hospital, Nanjing
Tianjin Medical University Cancer Institute & Hospital, Tianjin
Oncomed, Timișoara
Spitalul Clinic Municipal de Urgenta Timisoara, Timișoara
Sir Run Run Shaw Hospital School of Medicine, Zhejiang University, Hangzhou
Zhejiang Cancer Hospital, Hangzhou
Fujian Medical University Union Hospital, Fuzhou
Guz Clinical Oncology Dispensary #1, Krasnodar
GBUZ of Stavropol Territory Pyatigorsk Oncology Dispensary, Pyatigorsk
Radiotherapy Center CJ radioterapie si chimioterapie adulti, Floreşti
Hunan Cancer Hospital, Changsha
Tongji Hospital, Wuhan
"Sp. Jud. de Urg. Dr. Constantin Opris Baia Mare", Baia Mare
The First Affiliated Hospital of Zhengzhou University, Zhengzhou
Henan Cancer Hospital, Zhengzhou
Republican Clinical Oncology Dispensary, Ufa
Sun Yat-Sen University Cancer Center, Guangzhou
Southern Medical University, Nanfang Hospital, Guangzhou
Spitalul Clinic Judetean de Urgenta Sibiu, Sibiu
West China Hospital, Sichuan University, Chengdu
GUZ Perm Regional Oncology Dispensary, Perm
Centrul de Oncologie Euroclinic, Iași
Institutul Regional de Oncologie Iasi, Lasi
"IRCCS Ospedale Oncologico Giovanni Paolo II", Bari
General Hospital of Ningxia Medical University, Yinchuan
Xin Jiang Tumor Hospital, Xin Jiang Medical University, Ürümqi
Oncovida - Centro de Oncologia da Bahia, Salvador
Hospital Bruno Born, Lajeado
New Hampshire Oncology Hematology - Concord, Concord
New Hampshire Oncology Hematology - Laconia, Laconia
Cliniques Universitaires Saint-Luc, Brussels
Instituto do Câncer do Ceará - Instituto do Câncer do Cear, Fortaleza
Cetus Hospital Dia Oncologia, Belo Horizonte
Hospital Erasto Gaertner, Curitiba
Hospital da Cidade de Passo Fundo, Passo Fundo
UPCO - Unidade de Pesquisa Clinica em Oncologia LTDA, Pelotas
Clinica de Neoplasias Litoral, Itajaí
Fundaçao dr Amaral Carvalho, Jaú
Hospital de Base de São José do Rio Preto, São José do Rio Preto
Inca-RJ, Rio de Janeiro
IEP São Lucas, São Paulo
Casa de Saúde Santa Marcelina, São Paulo
The Ottawa Hospital Cancer Centre, Ottawa
Saint Michael's Hospital Li Ka Shing Knowledge Institute, Toronto
Mount Sinai Hospital, Toronto
Princess Margaret Hospital, Toronto
Hopital Notre-Dame du CHUM, Montreal
McGill University Health Centre - Montreal General Hospital, Montreal
FN Hradec Kralove, Hradec Králové
Fakultni nemocnice Olomouc, Olomouc
Masarykuv onkologicky ustav, Brno
Vseobecna fakultni nemocnice v Praze, Prague
Nemocnice Na Bulovce, Prague
Centre Antoine Lacassagne, Nice
Debreceni Egyetem Klinikai Központ, Debrecen
Aichi Cancer Center Hospital, Nagoya
National Cancer Center Hospital East, Kashiwa
National Hospital Organization Shikoku Cancer Center, Matsuyama
Hokkaido University Hospital, Sapporo
Kobe City Medical Center General Hospital, Kobe
Saku Central Hospital Advanced Care Center, Saku
Osaka University Hospital, Suita
Saitama Cancer Center, Kita-Adachi
Shizuoka Cancer Center, Sunto
Tochigi Cancer Center, Utsunomiya
National Cancer Center Hospital, Chūō
Kyorin University Hospial, Mitaka
Chiba Cancer Center, Chiba
Gifu University Hospital, Gifu
Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka
Hospital of Lithuanian University of Health sciences, Kaunas
Hospital of Lithuanian University of Health Sciences, Kaunas
Respublikine Panevezio ligonine, Panevezys
National Cancer Institute, Vilnius
Klaipeda University Hospital, Klaipėda
Vilniaus Universiteto ligonines Santariskiu Klinikos, Vilnius
Siauliai County Hospital, Šiauliai
NZOZ Centrum Medyczne HCP Lecznictwo Stacjonarne, Poznan
Centrum Onkologii im. F.Lukaszczyka, Bydgoszcz
Szpital Specjalistyczny im. L. Rydygiera w Krakowie, Krakow
Europejskie Centrum Zdrowia Otwock, Szpital im. F. Chopina, Otwock
Centrum Onkologii Instytut im. M. Sklodowskiej-Curie, Warsaw
Magodent sp. z o.o. Szpital Onkologiczny, Warsaw
Szpital Specjalistyczny w Brzozowie Podkarpacki Ośrodek Onko, Brzozów
Wojewodzkie Centrum Onkologii w Gdansku, Gdansk
Zachodniopomorskie Centrum Onkologii, Szczecin
Wojewodzki Szpital Specjalistyczny im. M.Kopernika, Lodz
Med Life, Bucharest
Spitalul Clinic CF 2, Bucharest
Institutul Clinic Fundeni, Bucharest
Seoul National University Bundang Hospital, Seongnam
Samsung Medical Center, Seoul
Asan medical Center, Seoul
Seoul National University Hospital, Seoul
Institut Català d'Oncologia-Hospital Germans Trias i Pujol, Badalona
C.A.AV-H.Ntra.Sra.de Sonsoles, Ávila
H.del Mar, Barcelona
Hospital Universitario Vall d'Hebrón, Barcelona
H.Sta.Creu i St.Pau, Barcelona
H.U. de Burgos, Burgos
Institut Catalá d´Oncología (I.C.O.), L'Hospitalet de Llobregat
Aberdeen Royal Infirmary, Aberdeen
The Beatson West Of Scotland Cancer Centre, Glasgow
Royal Surrey County Hospital, Guildford
The Royal Marsden Hospital, Sutton
The Royal Marsden NHS Foundation Trust - Royal Marsden Hospital, Sutton
Belfast City Hospital, Belfast
St. Georges Hospital, London
Christie Hospital NHS Foundation Trust, Manchester
Southampton University Hospital, Southampton
Sumitomo Pharma America, Inc.
INDUSTRY