Pharmacodynamic and Pharmacokinetic Dose Ranging Study of Tiotropium Bromide Administered Via Respimat Device in Patients With Chronic Obstructive Pulmonary Disease (COPD)

PHASE2CompletedINTERVENTIONAL

Enrollment

202

Participants

Timeline

Start Date

March 1, 1998

Primary Completion Date

April 1, 1999

Conditions

Pulmonary Disease, Chronic Obstructive

Interventions

DRUG

Tiotropium 0.625 mcg/puff

DRUG

Tiotropium 1.25 mcg/puff

DRUG

Tiotropium 2.5 mcg/puff

DRUG

Tiotropium 5 mcg/puff

DRUG

Placebo solution

DRUG

Tiotropium-18 lactose powder

DRUG

Placebo lactose powder

DRUG

Tiotropium 10 mcg/puff

DEVICE

Respimat

DEVICE

Handihaler