A Study Comparing the Efficacy and Safety of Etrolizumab With Adalimumab and Placebo in Participants With Moderate to Severe Ulcerative Colitis (UC) in Participants Naive to Tumor Necrosis Factor (TNF) Inhibitors

PHASE3CompletedINTERVENTIONAL
Enrollment

358

Participants

Timeline

Start Date

November 14, 2014

Primary Completion Date

March 2, 2020

Study Completion Date

May 25, 2020

Conditions
Ulcerative Colitis
Interventions
DRUG

Adalimumab

Adalimumab 160 milligrams (mg) will be administered subcutaneously (SC) at Week 0; 80 mg SC at Week 2; 40 mg SC at Weeks 4, 6 and 8.

OTHER

Adalimumab Placebo

Placebo matching to adalimumab will be administered SC at Weeks 0, 2, 4, 6, and 8.

DRUG

Etrolizumab

Etrolizumab 105 mg will be administered SC every 4 weeks (Q4W) up to Week 12 (at Weeks 0 \[Day 1\], 4, 8, and 12 \[clinical remitters only\]).

OTHER

Etrolizumab Placebo

Placebo matching to etrolizumab will be administered SC once every 4 weeks (Q4W) up to Week 12 (at Weeks 0 \[Day 1\], 4, 8, and 12 \[clinical remitters only\]).

Trial Locations (90)

0

RTS - Fundación Valle de Lili, Santiago de Cali

1407

"City Clinic UMHAC EOOD", Sofia

1680

Medical center CONVEX EOOD, Sofia

2091

"Med Center of International Institute of Clinical Trials LLC; Medical Center OK!Clinic+", Kyiv

2139

Concord Repatriation General Hospital, Concord

2600

"Medical Centre Asklepii, OOD", Dupnitsa

3011

Footscray Hospital; Gastroenterology, Footscray

3065

St Vincent's Hospital Melbourne, Fitzroy

3143

Tauranga Hospital, Tauranga

3248

Waikato Hospital, Hamilton

5000

Royal Adelaide Hospital, Adelaide

5042

Flinders Medical Centre, Bedford Park

5800

DCC Sv. Pantaleymon OOD, Pleven

Medical center Medconsult Pleven OOD, Pleven

6000

"Medical Center Nov Rehabilitatsionen Tsentar, EOOD", Stara Zagora

7002

MHAT - Ruse, AD, Rousse

8800

"MHAT Hadzhi Dimitar, OOD", Sliven

9010

MHAT 'Sv. Marina', EAD, Varna

9024

Petz Aladar Megyei Oktato Korhaz, Győr

10000

Clinical Hospital Sveti Duh, Zagreb

15586

Hospital Raja Perempuan Zainab II; Department of Medicine, Kota Bharu

21001

Private Small Enterprise Medical Center Pulse, Vinnytsia

21029

MCIC MC LLC Health Clinic, Vinnytsia

25100

Hospital Tengku Ampuan Afzan, Kuala Pahang

27310

Gaziantep University Medical Faculty Sahinbey Educational Research Hospital; Medical Oncology, Gaziantep

31000

Clinical Hospital Centre Osijek, Osijek

32803

Center For Digestive Health, Orlando

32806

Internal Medicine Specialists, Orlando

34668

Haydarpasa Numune Training and Research Hospital; Gastroenterology, Istanbul

36011

M.V. Sklifosovskyi Poltava RCH Dept of Gastroenterology HSEIU UMSA, Poltava

40022

CI of SRC Sumy RCH Dept of Gasroenterology Sumy SU MI, Sumy

41380

Kocaeli Universitesi Tip Fakultesi, Kocaeli

44060

Great Lakes Gastroenterology Research, LLC, Mentor

49074

SI inst. of Gastroenterology of NAMSU Dept of Stomach & Duodenum Diseases, D&ThN SI DMA of MoHU, Dnipropetrovsk

50009

Hospital of Lithuanian University of Health. Sciences Kaunas Clinics, Kaunas

56000

Pusat Perubatan Universiti Kebangsaan Malaysia, Kuala Lumpur

58002

RCNECRCH Dept of Surgery, SHEI Ukr BSMU, Chernivtsi

59100

University Malaya Medical Centre, Kuala Lumpur

61039

GI L.T.Malaya Therapy National Institute of the NAMS of Ukraine, Kharkiv

66606

Cotton-O'Neil Clinical Research Center, Digestive Health, Topeka

69104

Zaporizhzhia SMU, Zaporizhzhia

69106

LLC Diaservis, Zaporizhzhia

69495

Centre Hospitalier Lyon Sud, Pierre-Bénite

73000

CI Kherson Afanasii and Olha Tropiny City Clinical Hospital, Kherson

88018

A.Novak Transcarpathian Regional Clinical Hospital, Uzhhorod

92288

Klaipeda Seamen's Hospital, Public Institution, Klaipėda

194044

Center of Emergency and Radiation Medicine; Pulmonology, Saint Petersburg

197022

Pavlov First Saint Petersburg State Medical University, Saint Petersburg

197110

SBIH City Clinical Hospital #31, Saint Petersburg

"SPb SHI City Hospital #9", Saint Petersburg

355018

"FSBEI HE Stavropol State Medical University of Ministry of Healthcare of Russian Federation", Stavropol

394066

Voronezh Regional Clinical Hospital #1, Voronezh

630117

"FSBI Scientific Research Institute of Physyology and Basic Medicine under the SB of RAMS", Novosibirsk

644013

BHI of Omsk region Clinical Oncology Dispensary, Omsk

656038

SBEI HPE Altai State Medical University of MoH and SD; Out-patient Department, Barnaul

B7600DHK

Centro de Investigaciones Medicas Mar Del Plata, Mar del Plata

60430-370

Hospital Universitario Walter Cantidio - UFC, Fortaleza

41110-170

Hospital Universitario Prof Edgar Santos-Ufba; Ambulatorio Magalhaes Neto 3Andar- Dermatologia, Salvador

80430-160

Centro Digestivo de Curitiba, Curitiba

90160-092

Hospital Ernesto Dornelles, Porto Alegre

09080-000

Pesquisare Saúde Sociedade Simples, Santo André

050025

Instituto de Coloproctologia ICO S.A.S., Medellín

500 05

Fakultni nemocnice Hradec Kralove, Hradec Králové

500 12

Hepato-Gastroenterologie HK, s.r.o., Hradec Králové

779 00

PreventaMed, s.r.o., Olomouc

532 03

Pardubicka krajska nemocnice, a.s., Pardubice

170 04

ISCARE a.s., Prague

711 10

University General Hospital of Heraklion, Heraklion

LV-5401

Central Outpatient Clinic, Daugavpils

LV-1002

Pauls Stradins Clinical University Hospital, Riga

LV-1079

"Digestive Diseases Center Gastro", Riga

LT-08661

Vilnius University Hospital Santariskiu Clinic, Public Institution; Cardiology, Vilnius

0620

North Shore Hospital, Auckland

Shakespeare Specialist Group, Takapuna

Unknown

Dunedin Hospital, Dunedin

Irkutsk State Medical Academy of Continuing Education, Irkutsk

40-645

Pro Familia Altera Sp z o.o., Katowice

40-660

Nzoz All-Medicus, Katowice

40-752

Uniwersyteckie Centrum Kliniczne im. prof. K. Gibinskiego SUM, Katowice

95-054

Centrum Opieki Zdrowotnej Orkan-Med, Ksawerów

90-349

AppleTreeClinics Sp. z o.o., Lodz

34-400

Allmedica Badania Kliniczne Sp z o.o. Sp K., Nowy Targ

35-055

Centrum Medyczne Medyk, Rzeszów

35-302

Gabinet Lekarski, Bartosz Korczowski, Rzeszów

70-351

Niepubliczny Zaklad Opieki Zdrowotnej SONOMED, Szczecin

02-653

Endoterapia PFG Sp. z o.o., Warsaw

53-114

LexMedica Osrodek Badan Klinicznych, Wroclaw

06110

Ankara Diskapi Yildirim Beyazit Training and Research Hospital; Gastroenterology, Ankara

01030

CNE Kyiv CCH #18, Kyiv

04107

CI of Kyiv RC Kyiv Regional Clinical Hospital, Kyiv

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT02171429 - A Study Comparing the Efficacy and Safety of Etrolizumab With Adalimumab and Placebo in Participants With Moderate to Severe Ulcerative Colitis (UC) in Participants Naive to Tumor Necrosis Factor (TNF) Inhibitors | Biotech Hunter | Biotech Hunter