A Study to Evaluate Long-term Outcomes Following Treatment With ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) and ABT-333 With or Without Ribavirin (RBV) in Adults With Genotype 1 Chronic Hepatitis C Virus (HCV) Infection

PHASE3CompletedINTERVENTIONAL
Enrollment

615

Participants

Timeline

Start Date

June 12, 2014

Primary Completion Date

May 13, 2021

Study Completion Date

May 13, 2021

Conditions
Chronic Hepatitis C Virus (HCV) Infection Genotype 1
Interventions
DRUG

ABT-450/r/ABT-267

Tablet for oral use

DRUG

ABT-333

Tablet for oral use

DRUG

Ribavirin (RBV)

Ribavirin was provided as 200 mg tablets, and dosed based on weight, 1000 to 1200 mg divided twice daily per local label. For example, for participants weighing \< 75 kg, RBV may have been taken orally as 2 tablets in the morning and 3 tablets in the evening which corresponds to a 1000 mg total daily dose. For participants weighing ≥ 75 kg, RBV may have been taken orally as 3 tablets in the morning and 3 tablets in the evening which corresponds to a 1200 mg total daily dose.

Trial Locations (48)

10029

The Mount Sinai Hospital /ID# 128682, New York

11040

North Shore University Hospital /ID# 126565, New Hyde Park

12601

Premier Medical Group - GI Division /ID# 127793, Poughkeepsie

14642

Univ Rochester Med Ctr /ID# 127655, Rochester

20010

Medstar Health Research Institute /ID# 128683, Washington D.C.

21228

Digestive Disease Associates - Catonsville /ID# 127624, Catonsville

21287

Johns Hopkins University /ID# 127791, Baltimore

28203

Atrium Health Carolinas Medical Center /ID# 127632, Charlotte

28677

Carolinas Center For Liver Dis /ID# 127788, Statesville

30342

Atlanta Gastro Assoc /ID# 126571, Atlanta

32256

Encore Borland-Groover Clinical Research /Id# 127781, Jacksonville

32610

University of Florida - Archer /ID# 127787, Gainesville

33136

University of Miami /ID# 127622, Miami

33414

South Florida Ctr Gastro, P.A. /ID# 126567, Wellington

34209

Bach and Godofsky Infec Dis /ID# 128685, Bradenton

38138

Gastro One /ID# 127792, Germantown

46202

Duplicate_Indiana University Health /ID# 126573, Indianapolis

48202

Henry Ford Health System /ID# 127783, Detroit

53715

Dean Clinic /ID# 126575, Madison

55446

Minnesota Gastroenterology PA /ID# 126579, Plymouth

63104

St. Louis University /ID# 126564, St Louis

74104

Options Health Research, LLC /ID# 127630, Tulsa

77004

Cure C Consortium /ID# 126570, Houston

78215

TX Liver Inst, Americ Res Corp /ID# 127623, San Antonio

78660

Austin Institute for Clinical Research /ID# 126562, Pflugerville

80045

Univ of Colorado Cancer Center /ID# 126568, Aurora

84123

Clinical Research Ctrs America /ID# 127780, Murray

85013

St. Josephs Hospital and Med Center /ID# 127800, Phoenix

87505

Southwest Care Center /ID# 127784, Santa Fe

90036

Ruane Clinical Research Group /ID# 126577, Los Angeles

93301

Franco Felizarta, Md /Id# 126569, Bakersfield

94115

California Pacific Medical Center /ID# 128681, San Francisco

98101

Virginia Mason - Seattle Orthapedics /ID# 130288, Seattle

98109

University of Washington /ID# 127785, Seattle

60611-2927

Northwestern University Feinberg School of Medicine /ID# 128684, Chicago

60637-1443

The University of Chicago Medical Center /ID# 126576, Chicago

70112-2699

Tulane University /ID# 127779, New Orleans

71105-6800

Louisana Research Center, LLC /ID# 126561, Shreveport

02215-5400

Beth Israel Deaconess Medical Center /ID# 126560, Boston

08234

AGA Clinical Research Associates, LLC /ID# 126578, Egg Harbor

07103

Rutgers New Jersey School of Medicine /ID# 128686, Newark

87102-4517

University of New Mexico /ID# 128859, Albuquerque

10032-3725

Columbia Univ Medical Center /ID# 126566, New York

Columbia Univ Medical Center /ID# 127621, New York

45267-2827

University of Cincinnati Physicians Company, LLC /ID# 127790, Cincinnati

02905

University Gastroenterology /ID# 127789, Providence

77521-2415

Inquest Clinical Research /ID# 126574, Baytown

77030-2783

Liver Associates of Texas, P.A /ID# 126563, Houston

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AbbVie

INDUSTRY