Effects of Ethanol on Oxycodone Pharmacokinetics in Healthy Volunteers

PHASE1CompletedINTERVENTIONAL
Enrollment

17

Participants

Timeline

Start Date

July 31, 2014

Primary Completion Date

August 31, 2014

Study Completion Date

August 31, 2014

Conditions
Healthy
Interventions
DRUG

Oxycodone

One capsule of 40 mg PF-00345439 Formulation K, single dose, administered with water, under fasting conditions

DRUG

Naltrexone

Single dose of 40 mg PF-00345439 under naltrexone block (50 mg of naltrexone administered by mouth 12 hours before, 30 minutes before,and 12 hours after study drug administration).

DRUG

Oxycodone

One capsule of 40 mg PF-00345439 Formulation K, single dose, administered with 40% ethanol, under fasting conditions

DRUG

Naltrexone

Single dose of 40 mg PF-00345439 under naltrexone block (50 mg of naltrexone administered by mouth 12 hours before, 30 minutes before, and 12 hours after study drug administration).

Trial Locations (2)

66211

Pfizer Investigational Site, Overland Park

66212

Pfizer Investigational Site, Overland Park

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pain Therapeutics

INDUSTRY

NCT02165930 - Effects of Ethanol on Oxycodone Pharmacokinetics in Healthy Volunteers | Biotech Hunter | Biotech Hunter