A Study Comparing the Efficacy and Safety of Etrolizumab With Adalimumab and Placebo in Participants With Moderate to Severe Ulcerative Colitis (UC) in Participants Naive to Tumor Necrosis Factor (TNF) Inhibitors

PHASE3CompletedINTERVENTIONAL
Enrollment

358

Participants

Timeline

Start Date

November 4, 2014

Primary Completion Date

February 19, 2020

Study Completion Date

March 19, 2020

Conditions
Ulcerative Colitis
Interventions
DRUG

Adalimumab

Adalimumab 160 milligrams (mg) will be administered subcutaneously (SC) at Week 0; 80 mg SC at Week 2; 40 mg SC at Weeks 4, 6, and 8.

OTHER

Adalimumab Placebo

Placebo matching to adalimumab will be administered SC at Weeks 0, 2, 4, 6, and 8.

DRUG

Etrolizumab

Etrolizumab 105 mg will be administered SC every 4 weeks (Q4W) up to Week 12 (at Weeks 0 \[Day 1\], 4, 8, and 12 \[clinical remitters only\]).

OTHER

Etrolizumab Placebo

Placebo matching to etrolizumab will be administered SC once every 4 weeks (Q4W) up to Week 12 (at Weeks 0 \[Day 1\], 4, 8, and 12 \[clinical remitters only\]).

Trial Locations (88)

1023

Medical Center of Limited Liability Company Medical Clinic Blagomed, Kyiv

1431

"UMHAT Sv. Ivan Rilski, EAD", Sofia

1527

UMHAT Tsaritsa Yoanna - ISUL, EAD, Sofia

2200

Bankstown-Lidcombe Hospital, Bankstown

3168

Monash Medical Centre, Clayton

4029

Royal Brisbane and Women's Hospital, Herston

4073

CI of Kyiv RC Regional Clinical Hospital #2, Kyiv

4101

Mater Hospital Brisbane, South Brisbane

4102

Princess Alexandra Hospital, Woolloongabba

5000

MC Medica Plus, Veliko Tarnovo

6150

Fiona Stanley Hospital, Murdoch

10117

OÜ Innomedica, Tallinn

10138

East Tallinn Central Hospital, Tallinn

10617

West Tallinn Central Hospital, Tallinn

11000

Clinical Center Zvezdara, Belgrade

11040

Military Medical Academy, Belgrade

11070

Clinical Center Bezanijska Kosa, Belgrade

11080

Clinical Center Zemun, Belgrade

13419

North Estonia Medical Centre Foundation, Tallinn

23000

"General Hospital Djordje Joanovic; Gastroenterology", Zrenjanin

31201

Gastroenterology Associates of Central Georgia, Macon

32751

Center for Advanced Gastroenterology, Maitland

34000

Clinical Center Kragujevac, Kragujevac

34102

Gastroenterology Group of Naples, Naples

36011

M.V. Sklifosovskyi Poltava RCH Outpatient UMSA HSEIU Ukrainian Medical Stomatological Academy, Poltava

44160

Centro Integral en Reumatología S.A. de C.V. (CIRSA), Guadalajara

48098

Center for Digestive Health, Troy

48197

Huron Gastroenterology Associates, Ypsilanti

51014

Tartu University Hospital, Tartu

58002

RCI Chernivtsi RCH Gastroenterology Bukovinsky SMU, Chernivtsi

60637

University of Chicago Medical Center, Chicago

61037

CNE Prof. O.O. Shalimov Kharkiv City Clinical Hospital #2 of KCC, Kharkiv

61058

Communal Non-commercial Enterprise of Kharkiv Regional Council Regional Clinical Hospital, Kharkiv

61124

CHI Kharkiv City Clinical Hospital #13, Kharkiv

64000

Accelerium S. de R.L. de C.V., Monterrey

64460

Hospital Universitario Dr Jose Eleuterio Gonzalez; Universidad Autónoma de Nuevo León, Monterrey

69104

CI City Hospital #1, Zaporizhzhia

69118

CI City Hospital #7, Zaporizhzhia

75701

Tyler Research Institute, LLC, Tyler

78232

Wellness Clinical Research Center, San Antonio

80215

Rocky Mountain Gastroenterology Associates, P.L.L.C.; Gastroenterology, Lakewood

92110

Hôpital Beaujon, Clichy

94901

KM Management spol. s r.o., Nitra

119333

FSBIH Central Clinical Hospital of RAS, Moscow

123154

"FSBI State Scientific Centre of Coloproctology of the MoH of RF; Gastroenterology", Moscow

127015

Yusupov Hospital, Moskva

162600

Medical and Sanitary Division of Severstal, Cherepovets

194044

"FSMEI HPE Military Medical Academy n.a. S.M.Kirovof Minist", Saint Petersburg

194354

"SPb SBIH City Multy-field Hospital # 2; Intensive Pulmonology and Thoracal Surgery", Saint Petersburg

194356

Baltic Medicine, Saint Petersburg

196247

City Hospital #26, Saint Petersburg

198035

"LLC International Medical Centre SOGAZ", Saint Petersburg

344022

"SEIHPE Rostov SMU of MoH of RF", Rostov-on-Don

355017

Stavropol Regional Clinical Diagnostic Consultative Center, Stavropol

603126

"SBHI of NN region RCH of NN n.a. N.A.Semashko", Nizhny Novgorod

644043

"SBEI of HPE Omsk SMA Ministry of healthcare of RF", Omsk

656038

SBEI HPE Altai State Medical University of MoH and SD; Out-patient Department, Barnaul

X5003DCE

Instituto Medico DAMIC, Córdoba

70200-730

CCBR - Brasilia, Brasília

74535-170

Instituto Goiano de Gastroenterologia e Endoscopia Digestiva Ltda, Goiânia

30110-068

Hospital Felicio Rocho, Belo Horizonte

21941-913

Hospital Universitario Clementino Fraga Filho - UFRJ, Rio de Janeiro

90035-903

Hospital das Clinicas - UFRGS, Porto Alegre

18618-970

UNESP - Faculdade de Medicina da Universidade Estadual Paulista - Campus Botucatu, Botucatu

06202

CHU Nice - Hopital de l'Archet 2, Nice

Unknown

University of Hong Kong, Hong Kong

42-202

Centrum Medyczne Sw. Lukasza, Częstochowa

80-305

7 Szpital Marynarki Wojennej z Przychodnia SPZOZ im. W. Lasinskiego, Gdansk

31-637

NZOZ Centrum Medyczne ProMiMed, Krakow

90-349

AppleTreeClinics Sp. z o.o., Lodz

91-034

Med-Gastr Przychodnia Specjalistyczna, Lodz

20-015

Indywidualna Specjalistyczna Praktyka Lekarska, Lublin

20-582

GASTROMED Sp. z o.o., Lublin

10-561

Wojewodzki Specjalistyczny Szpital w Olsztynie, Olsztyn

60-529

SOLUMED Centrum Medyczne, Poznan

81-756

Specjalistyczna Praktyka Lekarska Dr med. Marek Horynski; endoskopia, Sopot

71-434

Twoja Przychodnia-Szczecinskie Centrum Medyczne, Szczecin

00-631

Centrum Zdrowia MDM, Warsaw

02-781

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy, Warsaw

50-220

EMC Instytut Medyczny S.A., Wroclaw

52-210

PlanetMed, Wroclaw

975 17

Fakultna nemocnica s poliklinikou F.D. Roosevelta, Banská Bystrica

066 01

Nemocnica A.Lena Humenne, n.o., Humenné

080 01

Gastro I, s.r.o., Prešov

979 01

Svet zdravia a.s., Rimavská Sobota

936 01

Accout Center s.r.o., Šahy

04107

Communal Institution of Kyiv Regional Council Kyiv Regional Clinical Hospital, Kyiv

02232

CNI Consultative and Diagnostic Center of Desnianskyi District of Kyiv, Kyiv

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT02163759 - A Study Comparing the Efficacy and Safety of Etrolizumab With Adalimumab and Placebo in Participants With Moderate to Severe Ulcerative Colitis (UC) in Participants Naive to Tumor Necrosis Factor (TNF) Inhibitors | Biotech Hunter | Biotech Hunter