A Randomized Trial Evaluating Rapid Delivery of Dose Escalated Hypofractionated Radiotherapy for Patients Diagnosed With Bone Metastases for Effective Palliation of Symptoms

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

167

Participants

Timeline

Start Date

August 6, 2014

Primary Completion Date

September 2, 2020

Study Completion Date

September 2, 2020

Conditions
Bone Metastases
Interventions
RADIATION

Hypofractionated Radiation Treatment

Participants receive standard hypofractionated regimen of 3 Gy x 10 fractions, 1 radiation treatment a day for 5 days in a row.

RADIATION

One Radiation Treatment

12 Gy x 1 fraction or 16 Gy x 1 fractions adaptively depending on the size of the metastases or gross tumor volume (GTV).

BEHAVIORAL

Questionnaire

Questionnaire completion at months 1, 2, 3, 4, and 6 and then every 3 months after that for at least 3 years. Questionnaires ask about pain, pain relief, and quality of life.

Trial Locations (3)

77030

University of Texas MD Anderson Cancer Center, Houston

85234

Banner MD Anderson Cancer Center, Gilbert

08043

MD Anderson Cancer Center at Cooper, Voorhees Township

All Listed Sponsors
lead

M.D. Anderson Cancer Center

OTHER

NCT02163226 - A Randomized Trial Evaluating Rapid Delivery of Dose Escalated Hypofractionated Radiotherapy for Patients Diagnosed With Bone Metastases for Effective Palliation of Symptoms | Biotech Hunter | Biotech Hunter