Molecular-Guided Therapy for Childhood Cancer

NACompletedINTERVENTIONAL
Enrollment

186

Participants

Timeline

Start Date

July 8, 2014

Primary Completion Date

January 18, 2024

Study Completion Date

January 18, 2024

Conditions
NeuroblastomaMedulloblastomaGliomaEpendymomaChoroid Plexus NeoplasmsCraniopharyngiomaDysembryoplastic Neuroepithelial TumorMeningiomaPrimitive Neuroectodermal Tumors (PNETs)Germ Cell TumorsRhabdomyosarcomaNon-rhabdomyosarcomaEwings SarcomaOsteosarcomaWilms TumorRenal Cell CarcinomaMalignant Rhabdoid TumorClear Cell SarcomaLiver Tumors
Interventions
DEVICE

Guided Therapy

A total of 200 neuroblastoma, brain tumor, and rare tumor patients will be treated. Guided therapy will allow the use of any therapeutic combination (up to 4 agents) provided it includes medications contained in the study report. All patients will be followed for survival, disease response, progression and safety. All patients will be treated according to the discretion of the treating oncologist and study committee (minimum 3 oncologists and one pharmacist). Extent of disease will be measured and assessed for changes throughout the course of the study and at 6-8 week intervals (every 2 cycles).

Trial Locations (19)

10467

The Children's Hospital at Montefiore, The Bronx

17033

Penn State Milton S. Hershey Medical Center and Children's Hospital, Hershey

28204

Levine Children's Hospital, Charlotte

29425

Medical University of South Carolina, Charleston

32806

Arnold Palmer Hospital for Children, Orlando

37232

Monroe Carrell Jr. Children's Hospital at Vanderbilt, Nashville

49503

Helen DeVos Children's Hospital, Grand Rapids

55404

Children's Hospital and Clinics on Minnesota, Minneapolis

63104

Cardinal Glennon Children's Medical Center, St Louis

64108

Children's Mercy Hospitals and Clinics, Kansas City

72202

Arkansas Children's Hospital, Little Rock

77030

Texas Children's Cancer and Hematology Centers, Houston

78723

Dell Children's Blood and Cancer Center, Austin

84113

Primary Children's Hospital, Salt Lake City

92123

Rady Children's Hospital, San Diego

96813

Kapiolani Medical Center for Women and Children, Honolulu

06106

Connecticut Children's Hospital, Hartford

Unknown

Randall Children's Hospital, Portland

American University of Beirut Medical Center, Beirut

All Listed Sponsors
collaborator

Translational Genomics Research Institute

OTHER

collaborator

Dell, Inc.

INDUSTRY

lead

Giselle Sholler

OTHER

NCT02162732 - Molecular-Guided Therapy for Childhood Cancer | Biotech Hunter | Biotech Hunter